Myocardial Infarction, Anterior Wall Clinical Trial
Official title:
Evaluation of Comprehensive Remote Ischemic Conditioning in ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
The primary objective of the CORIC-MI trial is to evaluate whether comprehensive (per, post plus delayed) remote ischemic conditioning (CORIC) as an adjunctive therapy in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) can improve left ventricular function and remodeling at 30 days assessed by cardiac magnetic resonance imaging (CMR) for a minimum follow-up period of 12 months.
ST-segment elevation myocardial infarction (STEMI) is a leading cause of mortality and
morbidity worldwide. Rapid admission and acute interventional treatment combined with modern
antithrombotic pharmacologic therapy frequently establish complete reperfusion and acutely
stabilize the patient, but the reperfusion itself adds further to the damage in the
myocardium compromising the long-term outcome. At present, remote ischemic conditioning (RIC)
is the most promising adjuvant therapy to reduce reperfusion injury in patients with STEMI.
However, myocardial remodeling continues for several weeks after a myocardial infarction.
Recent animal studies have shown that RIC may also help the heart muscle recover if applied
every day during the month after a heart attack.
The CORIC-MI trial is a single-center, randomized, controlled, parallel group, and open-label
trial, with blinded evaluation of the endpoints.The primary objective of the trial is to
evaluate whether comprehensive (per, post plus delayed) remote ischemic conditioning (CORIC)
as an adjunctive therapy in patients with STEMI undergoing primary percutaneous coronary
intervention (PPCI) can improve left ventricular function and remodeling at 30 days assessed
by cardiac magnetic resonance imaging (CMR) for a minimum follow-up period of 12 months.
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