Malignant Tumor of Small Intestine Metastatic to Liver Clinical Trial
Official title:
Study of "Same TCM Syndrome for Different Diseases" and "Same Treatment for Different Diseases" of Primary Hepatocellular Carcinoma and Colorectal Cancer Under the Perspective of System Science
Traditional Chinese medicine (TCM) syndrome is a core foundation of disease knowledge,
clinical diagnosis and treatment and curative effect evaluation in TCM. "Same TCM Syndrome
for Different Diseases" and "Same Treatment for Different Diseases" is one of the
characteristics of TCM syndrome differentiation and treatment.
This study is the "TCM disease syndrome combination" research baced on principles and
methods of system biology, which is through acquisition of primary hepatocellular carcinoma
(HCC) and colorectal cancer patients with TCM syndrome information, detection of clinical
indicators and genomic, proteomic, and metabolites changes, analyzing the correlation
between TCM syndromes and biological information, and revealing its biological material
characteristics and the molecular mechanisms of "Same TCM Syndrome for Different
Diseases";Developing and implementing the program of TCM syndrome differentiation and
treatment for HCC and colorectal cancer to evaluate the efficacy of TCM syndrome
based-treatment of HCC and colorectal cancer with TCM syndrom scores, clinical and systems
biological indicators, quality of life and survival rate, and to revealing the mechanism of
the "Same Treatment for Different Diseases".
| Status | Recruiting |
| Enrollment | 320 |
| Est. completion date | December 2018 |
| Est. primary completion date | August 2017 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years to 85 Years |
| Eligibility |
Inclusion Criteria: 1. Clinical diagnosis of primary liver cancer (HCC) and colorectal cancer after surgery. 2. Liver cancer and colorectal cancer liver and kidney yin deficiency and spleen qi deficiency syndrome diagnosis standard : Yin deficiency of liver and kidney and spleen qi deficiency syndrome see hypochondriac pain, waist and knee Limp, fever, night sweats, dry mouth and throat, fatigue, anorexia, abdominal distension after eating more, red or pale tongue, less moss or Light peel, pulse fine. Exclusion Criteria: (1) there is a serious heart, kidney, and other diseases of the hematopoietic system effect of drug evaluation factors; (2)Mental disorders (3)Digestive tract obstruction; (4) poor compliance. |
| Country | Name | City | State |
|---|---|---|---|
| China | Shang Hai TCM University | Shanghai |
| Lead Sponsor | Collaborator |
|---|---|
| Shanghai University of Traditional Chinese Medicine |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Complete patient recruitment | Complete transcriptome microarray detection | 24 months |