Assesse Prevalence of Acute Kidney Injury and Myocardial Injury After Non Cardiac Surgery Clinical Trial
Official title:
Assessment of Acute Kidney Injury as a Risk Factor for Myocardial Injury After Non Cardiac Surgery in Critical Patients
Acute kidney injury (AKI) affects approximately 20% of hospitalized patients and up to 67% of those admitted to an intensive care unit (ICU), making it among the most common organ dysfunctions among the critically ill.Major adverse cardiac events (MACE) after non cardiac surgery are a leading cause of morbidity and mortality. The reported incidence of postoperative myocardial infarction (POMI) among patients undergoing noncardiac surgery is between 3% and 6%.The aim of this study is to Identify the impact of acute kidney injury on the development of myocardial injury after non cardiac surgery and to correlate it with other risk factors of for MINS.
Acute kidney injury (AKI) is classically described as an abrupt or rapidly reversible
reduction in the excretion of nitrogenous waste products, including urea, nitrogen, and
creatinine. Acute kidney injury (AKI) affects approximately 20% of hospitalized patients and
up to 67% of those admitted to an intensive care unit (ICU), making it among the most common
organ dysfunctions among the critically ill. Depending on severity, AKI contributes to
short-term mortality rates between 40% and 70%, and survivors are at increased risk for
chronic kidney disease. Because surgical care and perioperative events and comorbidities
interact to contribute to renal dysfunction in different patterns than in nonsurgical
patients, surgical patients have unique risk factors for renal dysfunction.
Major adverse cardiac events (MACE) after non cardiac surgery are a leading cause of
morbidity and mortality. The reported incidence of postoperative myocardial infarction
(POMI) among patients undergoing noncardiac surgery is between 3% and 6%. Early recognition
and timely treatment of POMI after surgery are very important. Therefore, routinemonitoring
of cardiac troponin has been recommended to identify patients at risk of early postoperative
cardiovascular events after surgery. Myocardial injury after noncardiac surgery (MINS) is
defined as follows: myocardial injury caused by ischemia (that may or may not result in
necrosis), has prognostic relevance, and occurs duringor within 30 days after noncardiac
surgery. MINS can be measured by postoperative troponin elevation in the presence or absence
of clinical symptoms. MINS occurs in 8% to 22% of adults undergoing major non
cardiacsurgery. To date, there have been few studies investigatingthe risk factors of MINS
in critical patients.
The postoperative AKI is a new risk factor of MINS in critical patients, and the impact of
AKI on MINS has not been evaluated in previous studies.
It is unclear by what mechanisms AKI influences theMINS in critical patients. A possible
explanation of this finding is that in patientswith postoperativeAKI, disturbed autonomic
nerve functions may induce postoperative hypotension and hypoperfusion, which may lead to
MINS .
Other idependent risk factors for myocardial injury after non cardiac surgery such as
emergency surgery and long time operation.The aim of this study is to Identify the impact of
acute kidney injury on the development of myocardial injury after non cardiac surgery and to
correlate it with other risk factors of for MINS.
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