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PEEP and V/Q Mismatch in Premature Infants

Infant, Premature, Diseases Clinical Trial

Official title:
Selecting PEEP in Ventilated Premature Infants by Reducing Ventilation/Perfusion Mismatch: a Pilot Feasibility Study

Clinical Trial Summary

Positive end-expiratory pressure (PEEP) is used in premature infants receiving mechanical ventilation to maintain lungs open and facilitate gas exchange. When ventilation/perfusion mismatch is present, areas of the lung that are open for gas exchange do not match up with areas of the lung that are receiving blood for gas exchange. This study measures the feasibility of enrolling and completing study maneuvers in premature infants for a prospective study measuring the responsiveness of V/Q mismatch to changes in the amount (or level) of PEEP.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03109613
Study type Interventional
Source Children's Hospital of Philadelphia
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date April 11, 2016
Completion date August 8, 2018
View Details
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