Human Papillomavirus-Related Malignant Neoplasm Clinical Trial
Official title:
A Safety and Efficacy Study of Transcription Activator-like Effector Nucleases and Clustered Regularly Interspaced Short Palindromic Repeat/Cas9 in the Treatment of HPV-related Cervical Intraepithelial NeoplasiaⅠ
This is an open-label and triple cohort study of the safety and efficacy of TALEN and CRISPR/Cas9 to possibly treat HPV Persistency and human cervical intraepithelial neoplasiaⅠwithout invasion.
HPV persistent infection is the major causal factor of cervical intraepithelial neoplasia
(CIN) and cervical cancer. The important roles of E6 and E7 playing in HPV-driven
carcinogenesis make them attractive targets for therapeutic interventions. Previous
evidences showed that using designated TALEN and CRISPR/Cas9 as genome editing tool could
produce disruption of HPV16 and HPV18 E6/E7 DNA, significantly decreasing the expression of
E6/E7, inducing cell apoptosis and inhibiting cell lines growth.
This study will evaluate the safety and efficacy of TALEN-HPV E6/E7 and CRISPR/Cas9-HPV
E6/E7 in treating HPV Persistency and HPV-related Cervical Intraepithelial NeoplasiaⅠ
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