Triple Negative Breast Cancer Clinical Trial
Official title:
A Multicenter Phase 2 Study of the Glutaminase Inhibitor CB-839 in Combination With Paclitaxel in Patients With Advanced Triple Negative Breast Cancer (TNBC) Including Patients of African Ancestry and Non-African Ancestry
CX-839-007 is an open-label Phase 2 study of the combination of CB-839 with paclitaxel in participants of African ancestry and non-African ancestry with advanced triple negative breast cancer. Multiple single-arm cohorts will be enrolled in which 800 mg twice daily (BID) CB-839 will be administered in combination with the full approved dose of paclitaxel.
Participants will be enrolled into 4 cohorts, as follows: - Cohort 1: patients of African ancestry with 2 or more lines of prior therapy for metastatic disease - Cohort 2: patients of African ancestry with no prior lines of therapy for metastatic disease - Cohort 3: same as cohort 1 but in patients of non-African ancestry - Cohort 4: same as cohort 2 but in patients of non-African ancestry ;
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