Node Positive HER2 Negative Breast Cancer Clinical Trial
Official title:
A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for HER2 Negative Breast Cancer: The ABC Trial
| Verified date | April 2023 |
| Source | Alliance for Clinical Trials in Oncology |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
This randomized phase III trial studies how well aspirin works in preventing the cancer from coming back (recurrence) in patients with human epidermal growth factor receptor 2 (HER2) negative breast cancer after chemotherapy, surgery, and/or radiation therapy. Aspirin is a drug that reduces pain, fever, inflammation, and blood clotting. It is also being studied in cancer prevention. Giving aspirin may reduce the rate of cancer recurrence in patients with breast cancer.
| Status | Terminated |
| Enrollment | 3021 |
| Est. completion date | February 15, 2023 |
| Est. primary completion date | December 13, 2021 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years to 69 Years |
| Eligibility | - Histologic documentation of women or men with node positive, HER2 negative, anatomic stage II or III breast carcinoma and high risk node negative (defined as estrogen receptor [ER] and progesterone receptor [PR] negative and tumor size > 2 cm) within one year of diagnosis and free of recurrence; patients with pN1mic are eligible; if neoadjuvant therapy was received, either initial clinical stage (determined by physical and or radiologic examination) or post-operative pathologic stage can be used for eligibility purposes, with the higher stage determining eligibility; histologic documentation of node positivity is required; bilateral breast cancers are allowed, as long as both cancers are HER2 negative and at least one of the cancers meets eligibility - Any ER/progesterone receptor (PgR) status allowed - Prior adjuvant treatment with chemotherapy and/or endocrine therapy, as determined by the treating physician, is allowed; the last dose of chemotherapy or radiation therapy must be at least 30 days prior to study registration; concurrent hormonal therapy will be allowed - Regular nonsteroidal anti-inflammatory drug (NSAID)/aspirin use at any dose (including baby aspirin) (defined as >= 5 days per week) is allowed if aspirin and/or NSAIDs are stopped for 30 days prior to study entry and throughout the study period; participants will be encouraged to use acetaminophen for minor pain and fever - Patients must be enrolled within 1 year after diagnosis - Eastern Cooperative Oncology Group (ECOG) performance status 0-2 - Patients with a prior history of gastric/duodenal ulcers documented on endoscopy can be enrolled as long as the ulcers did not cause bleeding requiring a blood transfusion/major intervention; for patients who are Helicobacter pylori positive, a course of Helicobacter pylori eradication treatment must have been completed - No history of gastrointestinal bleeding (GI) bleeding requiring a blood transfusion, endoscopic or operative intervention - No history of any prior stroke (hemorrhagic or ischemic) - No concurrent anticoagulation with warfarin or heparin/heparin analogues, clopidogrel, oral direct thrombin inhibitors, or direct factor XA inhibitors - No history of atrial fibrillation or myocardial infarction - No history of grade 4 hypertension, defined as hypertension resulting in life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis) - No chronic (duration > 30 days) daily use of oral steroids - No known allergy to aspirin - No prior malignancy of any type (including ductal breast carcinoma in situ [DCIS]) within the past 5 years except for current diagnosis of breast cancer, and any prior diagnosis of basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix; patients with a prior history of breast cancer greater than 5 years from study screening may participate in this study - Concurrent enrollment on a non-chemotherapy treatment trial will be allowed, as long as that trial allows concurrent daily aspirin use |
| Country | Name | City | State |
|---|---|---|---|
| Canada | Cambridge Memorial Hospital | Cambridge | Ontario |
| Canada | PEI Cancer Treatment Centre-Queen Elizabeth Hospital | Charlottetown | Prince Edward Island |
| Canada | Cross Cancer Institute | Edmonton | Alberta |
| Canada | Kingston Health Sciences Centre | Kingston | Ontario |
| Canada | Grand River Regional Cancer Centre at Grand River Hospital | Kitchener | Ontario |
| Canada | London Regional Cancer Program | London | Ontario |
| Canada | The Vitalite Health Network - Dr Leon Richard Oncology Centre | Moncton | New Brunswick |
| Canada | CIUSSSEMTL-Hopital Maisonneuve-Rosemont | Montreal | Quebec |
| Canada | Allan Blair Cancer Centre | Regina | Saskatchewan |
| Canada | Atlantic Health Sciences Corporation-Saint John Regional Hospital | Saint John | New Brunswick |
| Canada | Saskatoon Cancer Centre | Saskatoon | Saskatchewan |
| Canada | Odette Cancer Centre- Sunnybrook Health Sciences Centre | Toronto | Ontario |
| Canada | BCCA-Vancouver Cancer Centre | Vancouver | British Columbia |
| Guam | FHP Health Center-Guam | Tamuning | |
| Puerto Rico | Advance Oncology Center | Aguadilla | |
| Puerto Rico | Doctor's Cancer Center-Arecibo | Arecibo | |
| Puerto Rico | Cancer Center-Metro Medical Center Bayamon | Bayamon | |
| Puerto Rico | Hematologia Oncologia San Pablo | Bayamon | |
| Puerto Rico | HIMA San Pablo Oncologic Hospital | Caguas | |
| Puerto Rico | Doctors Cancer Center | Manati | |
| Puerto Rico | Instituto Oncologia Moderna Ponce | Ponce | |
| Puerto Rico | Centro Comprensivo de Cancer de UPR | San Juan | |
| Puerto Rico | Primary Care Physician Group | San Juan | |
| Puerto Rico | San Juan City Hospital | San Juan | |
| Puerto Rico | San Juan Community Oncology Group | San Juan | |
| Puerto Rico | Centro de Hematologia y Oncologia del Sur | Santa Isabel | |
| United States | Hawaii Cancer Care - Savio | 'Aiea | Hawaii |
| United States | Pali Momi Medical Center | 'Aiea | Hawaii |
| United States | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii |
| United States | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii |
| United States | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington |
| United States | Hendrick Medical Center | Abilene | Texas |
| United States | Hickman Cancer Center | Adrian | Michigan |
| United States | Riverwood Healthcare Center | Aitkin | Minnesota |
| United States | Cleveland Clinic Akron General | Akron | Ohio |
| United States | Summa Health System - Akron Campus | Akron | Ohio |
| United States | Phoebe Putney Memorial Hospital | Albany | Georgia |
| United States | Mayo Clinic Health System in Albert Lea | Albert Lea | Minnesota |
| United States | Lovelace Medical Center-Saint Joseph Square | Albuquerque | New Mexico |
| United States | Presbyterian Kaseman Hospital | Albuquerque | New Mexico |
| United States | University of New Mexico Cancer Center | Albuquerque | New Mexico |
| United States | Christus Saint Frances Cabrini Hospital | Alexandria | Louisiana |
| United States | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania |
| United States | Aultman Alliance Community Hospital | Alliance | Ohio |
| United States | AdventHealth Altamonte | Altamonte Springs | Florida |
| United States | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah |
| United States | Mary Greeley Medical Center | Ames | Iowa |
| United States | McFarland Clinic PC - Ames | Ames | Iowa |
| United States | Community Hospital of Anaconda | Anaconda | Montana |
| United States | Cancer Care Center at Island Hospital | Anacortes | Washington |
| United States | Kaiser Permanente-Anaheim | Anaheim | California |
| United States | Alaska Breast Care and Surgery LLC | Anchorage | Alaska |
| United States | Alaska Oncology and Hematology LLC | Anchorage | Alaska |
| United States | Alaska Women's Cancer Care | Anchorage | Alaska |
| United States | Anchorage Associates in Radiation Medicine | Anchorage | Alaska |
| United States | Anchorage Oncology Centre | Anchorage | Alaska |
| United States | Anchorage Radiation Therapy Center | Anchorage | Alaska |
| United States | Katmai Oncology Group | Anchorage | Alaska |
| United States | Providence Alaska Medical Center | Anchorage | Alaska |
| United States | AnMed Health Cancer Center | Anderson | South Carolina |
| United States | Saint Vincent Anderson Regional Hospital/Cancer Center | Anderson | Indiana |
| United States | Saint Joseph Mercy Hospital | Ann Arbor | Michigan |
| United States | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan |
| United States | Langlade Hospital and Cancer Center | Antigo | Wisconsin |
| United States | Kaiser Permanente-Deer Valley Medical Center | Antioch | California |
| United States | ThedaCare Regional Cancer Center | Appleton | Wisconsin |
| United States | ThedaCare Regional Medical Center - Appleton | Appleton | Wisconsin |
| United States | Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande | California |
| United States | PCR Oncology | Arroyo Grande | California |
| United States | Randolph Hospital | Asheboro | North Carolina |
| United States | AdventHealth Infusion Center Asheville | Asheville | North Carolina |
| United States | Duluth Clinic Ashland | Ashland | Wisconsin |
| United States | King's Daughter's Medical Center | Ashland | Kentucky |
| United States | Northwest Wisconsin Cancer Center | Ashland | Wisconsin |
| United States | University Cancer and Blood Center LLC | Athens | Georgia |
| United States | Emory Saint Joseph's Hospital | Atlanta | Georgia |
| United States | Emory University Hospital Midtown | Atlanta | Georgia |
| United States | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia |
| United States | Grady Health System | Atlanta | Georgia |
| United States | Kaiser Permanente-Glenlake Medical Center | Atlanta | Georgia |
| United States | Northside Hospital | Atlanta | Georgia |
| United States | Piedmont Hospital | Atlanta | Georgia |
| United States | Hematology Oncology Associates of Central New York-Auburn | Auburn | New York |
| United States | MultiCare Auburn Medical Center | Auburn | Washington |
| United States | Sutter Auburn Faith Hospital | Auburn | California |
| United States | Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California |
| United States | Augusta Oncology Associates PC-D'Antignac | Augusta | Georgia |
| United States | Augusta Oncology Associates PC-Wheeler | Augusta | Georgia |
| United States | Augusta University Medical Center | Augusta | Georgia |
| United States | Harold Alfond Center for Cancer Care | Augusta | Maine |
| United States | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado |
| United States | Rush - Copley Medical Center | Aurora | Illinois |
| United States | The Medical Center of Aurora | Aurora | Colorado |
| United States | University of Colorado Hospital | Aurora | Colorado |
| United States | Austin Cancer Centers-Central Austin | Austin | Texas |
| United States | Austin Cancer Centers-Northwest | Austin | Texas |
| United States | Austin Cancer Centers-Saint David's | Austin | Texas |
| United States | Mount Sinai Comprehensive Cancer Center at Aventura | Aventura | Florida |
| United States | IU Health West Hospital | Avon | Indiana |
| United States | Virginia Mason Bainbridge Island Medical Center | Bainbridge Island | Washington |
| United States | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon |
| United States | AIS Cancer Center at San Joaquin Community Hospital | Bakersfield | California |
| United States | Kaiser Permanente-Baldwin Park | Baldwin Park | California |
| United States | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri |
| United States | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland |
| United States | Kaiser Permanente-Woodlawn Medical Center | Baltimore | Maryland |
| United States | MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland |
| United States | MedStar Good Samaritan Hospital | Baltimore | Maryland |
| United States | Sinai Hospital of Baltimore | Baltimore | Maryland |
| United States | Eastern Maine Medical Center | Bangor | Maine |
| United States | Summa Health System - Barberton Campus | Barberton | Ohio |
| United States | Flaget Memorial Hospital | Bardstown | Kentucky |
| United States | Baton Rouge General Medical Center | Baton Rouge | Louisiana |
| United States | Hematology/Oncology Clinic PLLC | Baton Rouge | Louisiana |
| United States | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana |
| United States | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana |
| United States | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana |
| United States | Medical Center of Baton Rouge | Baton Rouge | Louisiana |
| United States | Ochsner Health Center-Summa | Baton Rouge | Louisiana |
| United States | Ochsner High Grove | Baton Rouge | Louisiana |
| United States | Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana |
| United States | Woman's Hospital | Baton Rouge | Louisiana |
| United States | Bronson Battle Creek | Battle Creek | Michigan |
| United States | McLaren Cancer Institute-Bay City | Bay City | Michigan |
| United States | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio |
| United States | Beaufort Memorial Hospital | Beaufort | South Carolina |
| United States | UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania |
| United States | Indu and Raj Soin Medical Center | Beavercreek | Ohio |
| United States | UM Upper Chesapeake Medical Center | Bel Air | Maryland |
| United States | Waldo County General Hospital | Belfast | Maine |
| United States | Overlake Medical Center | Bellevue | Washington |
| United States | Kaiser Permanente-Bellflower | Bellflower | California |
| United States | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington |
| United States | Gaston Hematology and Oncology Associates-Belmont | Belmont | North Carolina |
| United States | Strecker Cancer Center-Belpre | Belpre | Ohio |
| United States | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota |
| United States | Saint Charles Health System | Bend | Oregon |
| United States | Southwestern Vermont Medical Center | Bennington | Vermont |
| United States | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California |
| United States | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont |
| United States | Mac Neal Hospital | Berwyn | Illinois |
| United States | Suburban Hospital | Bethesda | Maryland |
| United States | Walter Reed National Military Medical Center | Bethesda | Maryland |
| United States | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania |
| United States | Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania |
| United States | Beverly Hospital | Beverly | Massachusetts |
| United States | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine |
| United States | Billings Clinic Cancer Center | Billings | Montana |
| United States | Saint Vincent Frontier Cancer Center | Billings | Montana |
| United States | Saint Vincent Healthcare | Billings | Montana |
| United States | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama |
| United States | Sanford Bismarck Medical Center | Bismarck | North Dakota |
| United States | McLaren Cancer Institute-Bloomfield | Bloomfield | Michigan |
| United States | Illinois CancerCare-Bloomington | Bloomington | Illinois |
| United States | Saint Joseph Medical Center | Bloomington | Illinois |
| United States | Saint Elizabeth Boardman Hospital | Boardman | Ohio |
| United States | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho |
| United States | Saint Luke's Mountain States Tumor Institute | Boise | Idaho |
| United States | Central Care Cancer Center - Bolivar | Bolivar | Missouri |
| United States | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri |
| United States | McFarland Clinic PC-Boone | Boone | Iowa |
| United States | Beth Israel Deaconess Medical Center | Boston | Massachusetts |
| United States | Dana-Farber Cancer Institute | Boston | Massachusetts |
| United States | Massachusetts General Hospital Cancer Center | Boston | Massachusetts |
| United States | Boulder Community Hospital | Boulder | Colorado |
| United States | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado |
| United States | Bozeman Deaconess Hospital | Bozeman | Montana |
| United States | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota |
| United States | Cox Cancer Center Branson | Branson | Missouri |
| United States | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington |
| United States | Harrison Medical Center | Bremerton | Washington |
| United States | Lafayette Family Cancer Center-EMMC | Brewer | Maine |
| United States | Ocean Medical Center | Brick | New Jersey |
| United States | United Hospital Center | Bridgeport | West Virginia |
| United States | IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan |
| United States | Saint Joseph Mercy Brighton | Brighton | Michigan |
| United States | Steward Saint Elizabeth's Medical Center | Brighton | Massachusetts |
| United States | Wellmont Bristol Regional Medical Center | Bristol | Tennessee |
| United States | Wellmont Medical Associates Oncology and Hematology-Bristol | Bristol | Tennessee |
| United States | Wellmont Medical Associates-Bristol | Bristol | Virginia |
| United States | Jacobi Hospital | Bronx | New York |
| United States | Lincoln Medical and Mental Health Center | Bronx | New York |
| United States | Montefiore Medical Center - Moses Campus | Bronx | New York |
| United States | Montefiore Medical Center-Einstein Campus | Bronx | New York |
| United States | Montefiore Medical Center-Weiler Hospital | Bronx | New York |
| United States | Ascension Southeast Wisconsin Hospital - Elmbrook Campus | Brookfield | Wisconsin |
| United States | Kings County Hospital | Brooklyn | New York |
| United States | New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York |
| United States | Henry Ford Cancer Institute-Downriver | Brownstown | Michigan |
| United States | Saint Joseph Regional Cancer Center | Bryan | Texas |
| United States | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania |
| United States | Roswell Park Cancer Institute | Buffalo | New York |
| United States | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California |
| United States | Highline Medical Center-Main Campus | Burien | Washington |
| United States | Kaiser Permanente-Burke Medical Center | Burke | Virginia |
| United States | Mills-Peninsula Medical Center | Burlingame | California |
| United States | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin |
| United States | Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina |
| United States | Lahey Hospital and Medical Center | Burlington | Massachusetts |
| United States | University of Vermont and State Agricultural College | Burlington | Vermont |
| United States | University of Vermont Medical Center | Burlington | Vermont |
| United States | Fairview Ridges Hospital | Burnsville | Minnesota |
| United States | Minnesota Oncology - Burnsville | Burnsville | Minnesota |
| United States | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana |
| United States | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho |
| United States | Cambridge Medical Center | Cambridge | Minnesota |
| United States | Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California |
| United States | Aultman Health Foundation | Canton | Ohio |
| United States | Hematology and Oncology Associates Inc | Canton | Ohio |
| United States | IHA Hematology Oncology Consultants-Canton | Canton | Michigan |
| United States | Illinois CancerCare-Canton | Canton | Illinois |
| United States | Mercy Medical Center | Canton | Ohio |
| United States | Saint Joseph Mercy Canton | Canton | Michigan |
| United States | Saint Francis Medical Center | Cape Girardeau | Missouri |
| United States | Southeast Cancer Center | Cape Girardeau | Missouri |
| United States | Memorial Hospital of Carbondale | Carbondale | Illinois |
| United States | IU Health North Hospital | Carmel | Indiana |
| United States | Mercy San Juan Medical Center | Carmichael | California |
| United States | Caro Cancer Center | Caro | Michigan |
| United States | Carson Tahoe Regional Medical Center | Carson City | Nevada |
| United States | SIH Cancer Institute | Carterville | Illinois |
| United States | Illinois CancerCare-Carthage | Carthage | Illinois |
| United States | Rex Hematology Oncology Associates-Cary | Cary | North Carolina |
| United States | Waverly Hematology Oncology | Cary | North Carolina |
| United States | Eden Hospital Medical Center | Castro Valley | California |
| United States | Sandra L Maxwell Cancer Center | Cedar City | Utah |
| United States | Mercy Hospital | Cedar Rapids | Iowa |
| United States | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa |
| United States | AdventHealth Celebration | Celebration | Florida |
| United States | Rocky Mountain Cancer Centers - Centennial | Centennial | Colorado |
| United States | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio |
| United States | Miami Valley Hospital South | Centerville | Ohio |
| United States | Centralia Oncology Clinic | Centralia | Illinois |
| United States | Providence Regional Cancer System-Centralia | Centralia | Washington |
| United States | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania |
| United States | Chambersburg Hospital | Chambersburg | Pennsylvania |
| United States | Cancer Center of Kansas - Chanute | Chanute | Kansas |
| United States | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina |
| United States | Geauga Hospital | Chardon | Ohio |
| United States | Medical University of South Carolina | Charleston | South Carolina |
| United States | Novant Health Presbyterian Medical Center | Charlotte | North Carolina |
| United States | Oncology Specialists of Charlotte | Charlotte | North Carolina |
| United States | Southern Oncology Specialists-Charlotte | Charlotte | North Carolina |
| United States | Memorial Hospital | Chattanooga | Tennessee |
| United States | IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan |
| United States | Saint Joseph Mercy Chelsea | Chelsea | Michigan |
| United States | Saint Luke's Hospital | Chesterfield | Missouri |
| United States | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming |
| United States | Advocate Illinois Masonic Medical Center | Chicago | Illinois |
| United States | Mount Sinai Hospital Medical Center | Chicago | Illinois |
| United States | Presence Resurrection Medical Center | Chicago | Illinois |
| United States | Swedish Covenant Hospital | Chicago | Illinois |
| United States | University of Chicago Comprehensive Cancer Center | Chicago | Illinois |
| United States | University of Illinois | Chicago | Illinois |
| United States | Weiss Memorial Hospital | Chicago | Illinois |
| United States | Adventist Health Cancer Care Center Chico | Chico | California |
| United States | Enloe Medical Center | Chico | California |
| United States | Adena Regional Medical Center | Chillicothe | Ohio |
| United States | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin |
| United States | Bethesda North Hospital | Cincinnati | Ohio |
| United States | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Anderson | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio |
| United States | The Christ Hospital | Cincinnati | Ohio |
| United States | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio |
| United States | TriHealth Cancer Institute-Westside | Cincinnati | Ohio |
| United States | Clackamas Radiation Oncology Center | Clackamas | Oregon |
| United States | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon |
| United States | Hematology Oncology Consultants-Clarkston | Clarkston | Michigan |
| United States | McLaren Cancer Institute-Clarkston | Clarkston | Michigan |
| United States | Newland Medical Associates-Clarkston | Clarkston | Michigan |
| United States | Morton Plant Hospital | Clearwater | Florida |
| United States | Wake Forest University at Clemmons | Clemmons | North Carolina |
| United States | Case Western Reserve University | Cleveland | Ohio |
| United States | MetroHealth Medical Center | Cleveland | Ohio |
| United States | Prisma Health Cancer Institute - Laurens | Clinton | South Carolina |
| United States | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina |
| United States | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan |
| United States | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa |
| United States | Mercy Cancer Center-West Lakes | Clive | Iowa |
| United States | Community Cancer Institute | Clovis | California |
| United States | University Oncology Associates | Clovis | California |
| United States | AdventHealth Infusion Center Haywood | Clyde | North Carolina |
| United States | Billings Clinic-Cody | Cody | Wyoming |
| United States | Kootenai Medical Center | Coeur d'Alene | Idaho |
| United States | Coffeyville Regional Medical Center | Coffeyville | Kansas |
| United States | Main Line Health Center-Collegeville | Collegeville | Pennsylvania |
| United States | Integrity Oncology PLLC-Collierville | Collierville | Tennessee |
| United States | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado |
| United States | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado |
| United States | UCHealth Memorial Hospital Central | Colorado Springs | Colorado |
| United States | University of Missouri - Ellis Fischel | Columbia | Missouri |
| United States | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi |
| United States | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio |
| United States | Doctors Hospital | Columbus | Ohio |
| United States | Grant Medical Center | Columbus | Ohio |
| United States | John B Amos Cancer Center | Columbus | Georgia |
| United States | Mount Carmel East Hospital | Columbus | Ohio |
| United States | Mount Carmel Health Center West | Columbus | Ohio |
| United States | Ohio State University Comprehensive Cancer Center | Columbus | Ohio |
| United States | Riverside Methodist Hospital | Columbus | Ohio |
| United States | The Mark H Zangmeister Center | Columbus | Ohio |
| United States | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire |
| United States | MD Anderson in The Woodlands | Conroe | Texas |
| United States | Cookeville Regional Medical Center | Cookeville | Tennessee |
| United States | Mercy Hospital | Coon Rapids | Minnesota |
| United States | Mary Imogene Bassett Hospital | Cooperstown | New York |
| United States | Bay Area Hospital | Coos Bay | Oregon |
| United States | UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida |
| United States | Baptist Health Corbin | Corbin | Kentucky |
| United States | Commonwealth Cancer Center-Corbin | Corbin | Kentucky |
| United States | City of Hope Corona | Corona | California |
| United States | Good Samaritan Hospital | Corvallis | Oregon |
| United States | UC Irvine Health Cancer Center-Newport | Costa Mesa | California |
| United States | Alegent Health Mercy Hospital | Council Bluffs | Iowa |
| United States | Northshore Oncology Associates-Covington | Covington | Louisiana |
| United States | Greater Regional Medical Center | Creston | Iowa |
| United States | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky |
| United States | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri |
| United States | Aurora Saint Luke's South Shore | Cudahy | Wisconsin |
| United States | Northside Hospital-Forsyth | Cumming | Georgia |
| United States | Mass General/North Shore Cancer Center | Danvers | Massachusetts |
| United States | Carle on Vermilion | Danville | Illinois |
| United States | Danville Regional Medical Center | Danville | Virginia |
| United States | Geisinger Medical Center | Danville | Pennsylvania |
| United States | Southern Cancer Center PC-Daphne | Daphne | Alabama |
| United States | Mercy Fitzgerald Hospital | Darby | Pennsylvania |
| United States | Genesis Cancer Care Institute | Davenport | Iowa |
| United States | Genesis Medical Center - East Campus | Davenport | Iowa |
| United States | Iowa Cancer Specialists | Davenport | Iowa |
| United States | Sutter Davis Hospital | Davis | California |
| United States | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio |
| United States | Good Samaritan Hospital - Dayton | Dayton | Ohio |
| United States | Miami Valley Hospital | Dayton | Ohio |
| United States | Miami Valley Hospital North | Dayton | Ohio |
| United States | Halifax Health Medical Center-Centers for Oncology | Daytona Beach | Florida |
| United States | Beaumont Hospital - Dearborn | Dearborn | Michigan |
| United States | Henry Ford Medical Center-Fairlane | Dearborn | Michigan |
| United States | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois |
| United States | Decatur Memorial Hospital | Decatur | Illinois |
| United States | Dekalb Medical Center | Decatur | Georgia |
| United States | Essentia Health - Deer River Clinic | Deer River | Minnesota |
| United States | Broward Health North | Deerfield Beach | Florida |
| United States | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida |
| United States | Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois |
| United States | Delaware Health Center-Grady Cancer Center | Delaware | Ohio |
| United States | Delaware Radiation Oncology | Delaware | Ohio |
| United States | Grady Memorial Hospital | Delaware | Ohio |
| United States | Cancer Center of Colorado at Sloan's Lake | Denver | Colorado |
| United States | Colorado Blood Cancer Institute | Denver | Colorado |
| United States | Denver Health Medical Center | Denver | Colorado |
| United States | Kaiser Permanente-Franklin | Denver | Colorado |
| United States | National Jewish Health-Main Campus | Denver | Colorado |
| United States | Porter Adventist Hospital | Denver | Colorado |
| United States | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado |
| United States | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado |
| United States | Rocky Mountain Cancer Centers-Rose | Denver | Colorado |
| United States | Rose Medical Center | Denver | Colorado |
| United States | SCL Health Saint Joseph Hospital | Denver | Colorado |
| United States | The Women's Imaging Center | Denver | Colorado |
| United States | Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut |
| United States | Broadlawns Medical Center | Des Moines | Iowa |
| United States | Iowa Lutheran Hospital | Des Moines | Iowa |
| United States | Iowa Methodist Medical Center | Des Moines | Iowa |
| United States | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa |
| United States | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa |
| United States | Mercy Medical Center - Des Moines | Des Moines | Iowa |
| United States | Ascension Saint John Hospital | Detroit | Michigan |
| United States | Henry Ford Hospital | Detroit | Michigan |
| United States | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan |
| United States | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota |
| United States | Illinois CancerCare-Dixon | Dixon | Illinois |
| United States | Cancer Center of Kansas - Dodge City | Dodge City | Kansas |
| United States | Doylestown Hospital | Doylestown | Pennsylvania |
| United States | City of Hope Comprehensive Cancer Center | Duarte | California |
| United States | Dublin Methodist Hospital | Dublin | Ohio |
| United States | Epic Care-Dublin | Dublin | California |
| United States | Kaiser Permanente Dublin | Dublin | California |
| United States | Essentia Health Cancer Center | Duluth | Minnesota |
| United States | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota |
| United States | Kaiser Permanente-Gwinnett Medical Center | Duluth | Georgia |
| United States | Miller-Dwan Hospital | Duluth | Minnesota |
| United States | Northside Hospital - Duluth | Duluth | Georgia |
| United States | Saint Luke's Hospital of Duluth | Duluth | Minnesota |
| United States | Northeast Radiation Oncology Center | Dunmore | Pennsylvania |
| United States | Mercy Medical Center | Durango | Colorado |
| United States | Southwest Oncology PC | Durango | Colorado |
| United States | Duke University Medical Center | Durham | North Carolina |
| United States | Prisma Health Cancer Institute - Easley | Easley | South Carolina |
| United States | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan |
| United States | Cancer Institute at Saint Francis Hospital | East Hills | New York |
| United States | Fox Chase Cancer Center - East Norriton Hospital Outpatient Center | East Norriton | Pennsylvania |
| United States | Pocono Medical Center | East Stroudsburg | Pennsylvania |
| United States | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York |
| United States | University of Maryland Shore Medical Center at Easton | Easton | Maryland |
| United States | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin |
| United States | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin |
| United States | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin |
| United States | Mayo Clinic Health System-Eau Claire Clinic | Eau Claire | Wisconsin |
| United States | Saint Elizabeth Medical Center South | Edgewood | Kentucky |
| United States | Fairview Southdale Hospital | Edina | Minnesota |
| United States | Swedish Cancer Institute-Edmonds | Edmonds | Washington |
| United States | Shaw Cancer Center | Edwards | Colorado |
| United States | Carle Physician Group-Effingham | Effingham | Illinois |
| United States | Crossroads Cancer Center | Effingham | Illinois |
| United States | Cancer Center of Kansas - El Dorado | El Dorado | Kansas |
| United States | Hardin Memorial Hospital | Elizabethtown | Kentucky |
| United States | Mercy Cancer Center - Elk Grove | Elk Grove | California |
| United States | AMITA Health Alexian Brothers Medical Center | Elk Grove Village | Illinois |
| United States | Wake Forest University at Elkin | Elkin | North Carolina |
| United States | Christiana Care - Union Hospital | Elkton | Maryland |
| United States | Elmhurst Hospital Center | Elmhurst | New York |
| United States | Elmhurst Memorial Hospital | Elmhurst | Illinois |
| United States | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York |
| United States | Mercy Cancer Center-Elyria | Elyria | Ohio |
| United States | Bay Area Breast Surgeons Inc | Emeryville | California |
| United States | Epic Care Partners in Cancer Care | Emeryville | California |
| United States | Walter Knox Memorial Hospital | Emmett | Idaho |
| United States | Englewood Hospital and Medical Center | Englewood | New Jersey |
| United States | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado |
| United States | Swedish Medical Center | Englewood | Colorado |
| United States | Saint Elizabeth Hospital | Enumclaw | Washington |
| United States | Ephrata Cancer Center | Ephrata | Pennsylvania |
| United States | Ephrata Community Hospital | Ephrata | Pennsylvania |
| United States | UPMC Hillman Cancer Center Erie | Erie | Pennsylvania |
| United States | Green Bay Oncology - Escanaba | Escanaba | Michigan |
| United States | Illinois CancerCare-Eureka | Eureka | Illinois |
| United States | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois |
| United States | Deaconess Clinic Downtown | Evansville | Indiana |
| United States | Providence Regional Cancer Partnership | Everett | Washington |
| United States | Little Company of Mary Hospital | Evergreen Park | Illinois |
| United States | Main Line Health Center-Exton | Exton | Pennsylvania |
| United States | Fairbanks Memorial Hospital | Fairbanks | Alaska |
| United States | Inova Fair Oaks Hospital | Fairfax | Virginia |
| United States | Inova Schar Cancer Institute | Fairfax | Virginia |
| United States | JCHC McCreery Cancer Center | Fairfield | Iowa |
| United States | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio |
| United States | Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut |
| United States | Inova Fairfax Hospital | Falls Church | Virginia |
| United States | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota |
| United States | Sanford Broadway Medical Center | Fargo | North Dakota |
| United States | Sanford Roger Maris Cancer Center | Fargo | North Dakota |
| United States | Sanford South University Medical Center | Fargo | North Dakota |
| United States | Farmington Health Center | Farmington | Utah |
| United States | Parkland Health Center - Farmington | Farmington | Missouri |
| United States | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan |
| United States | Weisberg Cancer Treatment Center | Farmington Hills | Michigan |
| United States | Highlands Oncology Group PA - Fayetteville | Fayetteville | Arkansas |
| United States | Piedmont Fayette Hospital | Fayetteville | Georgia |
| United States | Saint Francis Hospital | Federal Way | Washington |
| United States | Virginia Mason Federal Way Medical Center | Federal Way | Washington |
| United States | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota |
| United States | Armes Family Cancer Center | Findlay | Ohio |
| United States | Blanchard Valley Hospital | Findlay | Ohio |
| United States | Orion Cancer Care | Findlay | Ohio |
| United States | Augusta Health Center for Cancer and Blood Disorders | Fishersville | Virginia |
| United States | Simonds-Sinon Regional Cancer Center | Fitchburg | Massachusetts |
| United States | Hunterdon Medical Center | Flemington | New Jersey |
| United States | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan |
| United States | Genesee Hematology Oncology PC | Flint | Michigan |
| United States | Genesys Hurley Cancer Institute | Flint | Michigan |
| United States | Hurley Medical Center | Flint | Michigan |
| United States | McLaren Cancer Institute-Flint | Flint | Michigan |
| United States | Singh and Arora Hematology Oncology PC | Flint | Michigan |
| United States | McLeod Regional Medical Center | Florence | South Carolina |
| United States | The New York Hospital Medical Center of Queens | Flushing | New York |
| United States | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin |
| United States | Saint Agnes Hospital/Agnesian Cancer Center | Fond Du Lac | Wisconsin |
| United States | Kaiser Permanente-Fontana | Fontana | California |
| United States | Poudre Valley Hospital | Fort Collins | Colorado |
| United States | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa |
| United States | Trinity Regional Medical Center | Fort Dodge | Iowa |
| United States | Broward Health Medical Center | Fort Lauderdale | Florida |
| United States | Holy Cross Hospital | Fort Lauderdale | Florida |
| United States | Regional Cancer Center-Lee Memorial Health System | Fort Myers | Florida |
| United States | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas |
| United States | Mercy Hospital Fort Smith | Fort Smith | Arkansas |
| United States | Saint Elizabeth Fort Thomas | Fort Thomas | Kentucky |
| United States | Parkview Hospital Randallia | Fort Wayne | Indiana |
| United States | Parkview Regional Medical Center | Fort Wayne | Indiana |
| United States | Essentia Health - Fosston | Fosston | Minnesota |
| United States | Beebe South Coastal Health Campus | Frankford | Delaware |
| United States | Ascension Saint Francis - Reiman Cancer Center | Franklin | Wisconsin |
| United States | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio |
| United States | Dayton Physicians LLC-Atrium | Franklin | Ohio |
| United States | Kaiser Permanente-Fremont | Fremont | California |
| United States | Palo Alto Medical Foundation-Fremont | Fremont | California |
| United States | Washington Hospital | Fremont | California |
| United States | Kaiser Permanente-Fresno | Fresno | California |
| United States | Unity Hospital | Fridley | Minnesota |
| United States | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho |
| United States | University of Florida Health Science Center - Gainesville | Gainesville | Florida |
| United States | Kaiser Permanente-Gaithersburg Medical Center | Gaithersburg | Maryland |
| United States | Illinois CancerCare-Galesburg | Galesburg | Illinois |
| United States | Western Illinois Cancer Treatment Center | Galesburg | Illinois |
| United States | University of Texas Medical Branch | Galveston | Texas |
| United States | Central Care Cancer Center - Garden City | Garden City | Kansas |
| United States | Rex Hematology Oncology Associates-Garner | Garner | North Carolina |
| United States | CaroMont Regional Medical Center | Gastonia | North Carolina |
| United States | Gaston Hematology and Oncology Associates | Gastonia | North Carolina |
| United States | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois |
| United States | Aurora Health Care Germantown Health Center | Germantown | Wisconsin |
| United States | Adams Cancer Center | Gettysburg | Pennsylvania |
| United States | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington |
| United States | Tacoma/Valley Radiation Oncology Centers-Gig Harbor | Gig Harbor | Washington |
| United States | Arizona Breast Cancer Specialists-Gilbert | Gilbert | Arizona |
| United States | Smilow Cancer Hospital Care Center at Glastonbury | Glastonbury | Connecticut |
| United States | UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland |
| United States | Virginia G Piper Cancer Care-Glendale | Glendale | Arizona |
| United States | Glens Falls Hospital | Glens Falls | New York |
| United States | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois |
| United States | Valley View Hospital Cancer Center | Glenwood Springs | Colorado |
| United States | Addison Gilbert Hospital | Gloucester | Massachusetts |
| United States | Mountain Blue Cancer Care Center | Golden | Colorado |
| United States | National Jewish Health-Western Hematology Oncology | Golden | Colorado |
| United States | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina |
| United States | Wayne Memorial Hospital | Goldsboro | North Carolina |
| United States | Aurora Cancer Care-Grafton | Grafton | Wisconsin |
| United States | Altru Cancer Center | Grand Forks | North Dakota |
| United States | CHI Health Saint Francis | Grand Island | Nebraska |
| United States | Grand Valley Oncology | Grand Junction | Colorado |
| United States | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado |
| United States | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan |
| United States | Mercy Health Saint Mary's | Grand Rapids | Michigan |
| United States | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan |
| United States | Central Care Cancer Center - Great Bend | Great Bend | Kansas |
| United States | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana |
| United States | Great Falls Clinic | Great Falls | Montana |
| United States | North Colorado Medical Center | Greeley | Colorado |
| United States | UCHealth Greeley Hospital | Greeley | Colorado |
| United States | Aurora BayCare Medical Center | Green Bay | Wisconsin |
| United States | Bellin Memorial Hospital | Green Bay | Wisconsin |
| United States | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin |
| United States | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin |
| United States | Cone Health Cancer Center | Greensboro | North Carolina |
| United States | UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania |
| United States | Dayton Physicians LLC-Wayne | Greenville | Ohio |
| United States | Prisma Health Cancer Institute - Butternut | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Faris | Greenville | South Carolina |
| United States | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina |
| United States | Saint Francis Cancer Center | Greenville | South Carolina |
| United States | Saint Francis Hospital | Greenville | South Carolina |
| United States | Wayne Hospital | Greenville | Ohio |
| United States | Greenwich Hospital | Greenwich | Connecticut |
| United States | Smilow Cancer Hospital Care Center at Greenwich | Greenwich | Connecticut |
| United States | Self Regional Healthcare | Greenwood | South Carolina |
| United States | Rocky Mountain Cancer Centers-Greenwood Village | Greenwood Village | Colorado |
| United States | Prisma Health Cancer Institute - Greer | Greer | South Carolina |
| United States | Baptist Cancer Center-Grenada | Grenada | Mississippi |
| United States | Legacy Mount Hood Medical Center | Gresham | Oregon |
| United States | William Beaumont Hospital-Grosse Pointe | Grosse Pointe | Michigan |
| United States | Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan |
| United States | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan |
| United States | Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan |
| United States | Mount Carmel Grove City Hospital | Grove City | Ohio |
| United States | Smilow Cancer Hospital Care Center - Guiford | Guilford | Connecticut |
| United States | Gulfport Memorial Hospital | Gulfport | Mississippi |
| United States | Hackensack University Medical Center | Hackensack | New Jersey |
| United States | Meritus Medical Center | Hagerstown | Maryland |
| United States | The Cancer Institute of New Jersey Hamilton | Hamilton | New Jersey |
| United States | Sentara Cancer Institute at Sentara CarePlex Hospital | Hampton | Virginia |
| United States | Virginia Oncology Associates-Hampton | Hampton | Virginia |
| United States | Cherry Tree Cancer Center | Hanover | Pennsylvania |
| United States | Kaiser Permanente - Harbor City | Harbor City | California |
| United States | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania |
| United States | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut |
| United States | Forrest General Hospital / Cancer Center | Hattiesburg | Mississippi |
| United States | Hattiesburg Clinic - Hematology/Oncology Clinic | Hattiesburg | Mississippi |
| United States | HaysMed University of Kansas Health System | Hays | Kansas |
| United States | Advocate South Suburban Hospital | Hazel Crest | Illinois |
| United States | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania |
| United States | Lehigh Valley Hospital-Hazleton | Hazleton | Pennsylvania |
| United States | Saint Peter's Community Hospital | Helena | Montana |
| United States | 21st Century Oncology-Henderson | Henderson | Nevada |
| United States | Cancer and Blood Specialists-Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada |
| United States | Las Vegas Cancer Center-Henderson | Henderson | Nevada |
| United States | Las Vegas Urology - Green Valley | Henderson | Nevada |
| United States | Las Vegas Urology - Pebble | Henderson | Nevada |
| United States | Maria Parham Hospital | Henderson | North Carolina |
| United States | OptumCare Cancer Care at Seven Hills | Henderson | Nevada |
| United States | Urology Specialists of Nevada - Green Valley | Henderson | Nevada |
| United States | AdventHealth Hendersonville | Hendersonville | North Carolina |
| United States | Hendersonville Hematology and Oncology at Pardee | Hendersonville | North Carolina |
| United States | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina |
| United States | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania |
| United States | Essentia Health Hibbing Clinic | Hibbing | Minnesota |
| United States | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois |
| United States | UCHealth Highlands Ranch Hospital | Highlands Ranch | Colorado |
| United States | South Carolina Cancer Specialists PC | Hilton Head Island | South Carolina |
| United States | Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee |
| United States | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida |
| United States | Bayshore Community Hospital | Holmdel | New Jersey |
| United States | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii |
| United States | Hawaii Cancer Care Inc-POB II | Honolulu | Hawaii |
| United States | Island Urology | Honolulu | Hawaii |
| United States | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii |
| United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
| United States | Kuakini Medical Center | Honolulu | Hawaii |
| United States | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii |
| United States | Queen's Cancer Center - Kuakini | Honolulu | Hawaii |
| United States | Queen's Medical Center | Honolulu | Hawaii |
| United States | Straub Clinic and Hospital | Honolulu | Hawaii |
| United States | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii |
| United States | Tripler Army Medical Center | Honolulu | Hawaii |
| United States | University of Hawaii Cancer Center | Honolulu | Hawaii |
| United States | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas |
| United States | Oncology Center of The South Incorporated | Houma | Louisiana |
| United States | Terrebonne General Medical Center | Houma | Louisiana |
| United States | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas |
| United States | Ben Taub General Hospital | Houston | Texas |
| United States | Houston Methodist Hospital | Houston | Texas |
| United States | Houston Methodist West Hospital | Houston | Texas |
| United States | Lyndon Baines Johnson General Hospital | Houston | Texas |
| United States | M D Anderson Cancer Center | Houston | Texas |
| United States | MD Anderson West Houston | Houston | Texas |
| United States | Lake Norman Hematology Oncology Specialists-Huntersville | Huntersville | North Carolina |
| United States | Southern Oncology Specialists-Huntersville | Huntersville | North Carolina |
| United States | Edwards Comprehensive Cancer Center | Huntington | West Virginia |
| United States | Saint Mary's Medical Center | Huntington | West Virginia |
| United States | Cape Cod Hospital | Hyannis | Massachusetts |
| United States | Cancer Center of Kansas-Independence | Independence | Kansas |
| United States | Centerpoint Medical Center LLC | Independence | Missouri |
| United States | Lallie Kemp Regional Medical Center | Independence | Louisiana |
| United States | Community Cancer Center East | Indianapolis | Indiana |
| United States | Community Cancer Center North | Indianapolis | Indiana |
| United States | Community Cancer Center South | Indianapolis | Indiana |
| United States | Franciscan Health Indianapolis | Indianapolis | Indiana |
| United States | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana |
| United States | IU Health Methodist Hospital | Indianapolis | Indiana |
| United States | Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana |
| United States | Springmill Medical Center | Indianapolis | Indiana |
| United States | Kaiser Permanente-Irvine | Irvine | California |
| United States | Swedish Cancer Institute-Issaquah | Issaquah | Washington |
| United States | Allegiance Health | Jackson | Michigan |
| United States | University of Mississippi Medical Center | Jackson | Mississippi |
| United States | Baptist MD Anderson Cancer Center | Jacksonville | Florida |
| United States | Onslow Memorial Hospital | Jacksonville | North Carolina |
| United States | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina |
| United States | Queens Hospital Center | Jamaica | New York |
| United States | Essentia Health - Jamestown Clinic | Jamestown | North Dakota |
| United States | Mercyhealth Hospital and Cancer Center - Janesville | Janesville | Wisconsin |
| United States | McFarland Clinic PC-Jefferson | Jefferson | Iowa |
| United States | Capital Region Southwest Campus | Jefferson City | Missouri |
| United States | Jersey City Medical Center | Jersey City | New Jersey |
| United States | Wellmont Medical Associates Oncology and Hematology-Johnson City | Johnson City | Tennessee |
| United States | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin |
| United States | UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania |
| United States | Joliet Oncology-Hematology Associates Limited | Joliet | Illinois |
| United States | Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas |
| United States | Kaiser Permanente Southwood | Jonesboro | Georgia |
| United States | Freeman Health System | Joplin | Missouri |
| United States | Mercy Hospital Joplin | Joplin | Missouri |
| United States | Borgess Medical Center | Kalamazoo | Michigan |
| United States | Bronson Methodist Hospital | Kalamazoo | Michigan |
| United States | West Michigan Cancer Center | Kalamazoo | Michigan |
| United States | Kalispell Regional Medical Center | Kalispell | Montana |
| United States | Presence Saint Mary's Hospital | Kankakee | Illinois |
| United States | Research Medical Center | Kansas City | Missouri |
| United States | Saint Luke's Hospital of Kansas City | Kansas City | Missouri |
| United States | The University of Kansas Cancer Center-South | Kansas City | Missouri |
| United States | Truman Medical Centers | Kansas City | Missouri |
| United States | University of Kansas Cancer Center - North | Kansas City | Missouri |
| United States | University of Kansas Cancer Center-West | Kansas City | Kansas |
| United States | CHI Health Good Samaritan | Kearney | Nebraska |
| United States | Heartland Hematology and Oncology | Kearney | Nebraska |
| United States | Ochsner Medical Center Kenner | Kenner | Louisiana |
| United States | Kaiser Permanente TownPark Comprehensive Medical Center | Kennesaw | Georgia |
| United States | Kadlec Clinic Hematology and Oncology | Kennewick | Washington |
| United States | Northwest Cancer Clinic | Kennewick | Washington |
| United States | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin |
| United States | Kaiser Permanente - Kensington Medical Center | Kensington | Maryland |
| United States | Novant Health Oncology Specialists-Kernersville | Kernersville | North Carolina |
| United States | First Dayton Cancer Care | Kettering | Ohio |
| United States | Greater Dayton Cancer Center | Kettering | Ohio |
| United States | Kettering Medical Center | Kettering | Ohio |
| United States | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois |
| United States | Cancer Center of Kansas-Kingman | Kingman | Kansas |
| United States | Kingman Regional Medical Center | Kingman | Arizona |
| United States | Regional Cancer Center at Indian Path Community Hospital | Kingsport | Tennessee |
| United States | Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee |
| United States | AdventHealth Kissimmee | Kissimmee | Florida |
| United States | University of Tennessee - Knoxville | Knoxville | Tennessee |
| United States | Community Howard Regional Health | Kokomo | Indiana |
| United States | Gundersen Lutheran Medical Center | La Crosse | Wisconsin |
| United States | Mayo Clinic Health System-Franciscan Healthcare | La Crosse | Wisconsin |
| United States | UC San Diego Moores Cancer Center | La Jolla | California |
| United States | Providence Regional Cancer System-Lacey | Lacey | Washington |
| United States | Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin |
| United States | Franciscan Saint Elizabeth Health - Lafayette East | Lafayette | Indiana |
| United States | Good Samaritan Medical Center | Lafayette | Colorado |
| United States | IU Health Arnett Cancer Care | Lafayette | Indiana |
| United States | Kaiser Permanente-Rock Creek | Lafayette | Colorado |
| United States | CHRISTUS Lake Charles Medical Center | Lake Charles | Louisiana |
| United States | Northwell Health/Center for Advanced Medicine | Lake Success | New York |
| United States | Lakeland Regional Health Hollis Cancer Center | Lakeland | Florida |
| United States | The Watson Clinic | Lakeland | Florida |
| United States | Monmouth Medical Center Southern Campus | Lakewood | New Jersey |
| United States | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado |
| United States | Saint Anthony Hospital | Lakewood | Colorado |
| United States | Saint Clare Hospital | Lakewood | Washington |
| United States | Fairfield Medical Center | Lancaster | Ohio |
| United States | Saint Mary Medical and Regional Cancer Center | Langhorne | Pennsylvania |
| United States | McLaren-Greater Lansing | Lansing | Michigan |
| United States | Mid-Michigan Physicians-Lansing | Lansing | Michigan |
| United States | Sparrow Hospital | Lansing | Michigan |
| United States | McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan |
| United States | Doctor's Hospital of Laredo | Laredo | Texas |
| United States | Kaiser Permanente - Largo Medical Center | Largo | Maryland |
| United States | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico |
| United States | 21st Century Oncology | Las Vegas | Nevada |
| United States | 21st Century Oncology-Fort Apache | Las Vegas | Nevada |
| United States | 21st Century Oncology-Vegas Tenaya | Las Vegas | Nevada |
| United States | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada |
| United States | Ann M Wierman MD LTD | Las Vegas | Nevada |
| United States | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada |
| United States | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada |
| United States | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada |
| United States | Desert West Surgery | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada |
| United States | Hope Cancer Care of Nevada | Las Vegas | Nevada |
| United States | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada |
| United States | Las Vegas Prostate Cancer Center | Las Vegas | Nevada |
| United States | Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada |
| United States | Las Vegas Urology - Pecos | Las Vegas | Nevada |
| United States | Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada |
| United States | Las Vegas Urology - Sunset | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at MountainView | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at Oakey | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada |
| United States | Summerlin Hospital Medical Center | Las Vegas | Nevada |
| United States | Sunrise Hospital and Medical Center | Las Vegas | Nevada |
| United States | University Cancer Center | Las Vegas | Nevada |
| United States | University Medical Center of Southern Nevada | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Central | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Northwest | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Southwest | Las Vegas | Nevada |
| United States | Scotland Memorial Hospital-Laurinburg Cancer Center | Laurinburg | North Carolina |
| United States | Lawrence Memorial Hospital | Lawrence | Kansas |
| United States | Northside Hospital - Gwinnett | Lawrenceville | Georgia |
| United States | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma |
| United States | MD Anderson League City | League City | Texas |
| United States | UTMB Cancer Center at Victory Lakes | League City | Texas |
| United States | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire |
| United States | Sechler Family Cancer Center | Lebanon | Pennsylvania |
| United States | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri |
| United States | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri |
| United States | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas |
| United States | Minimally Invasive Surgery Hospital | Lenexa | Kansas |
| United States | Beebe Medical Center | Lewes | Delaware |
| United States | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania |
| United States | Central Maine Medical Center | Lewiston | Maine |
| United States | Saint Joseph Regional Medical Center | Lewiston | Idaho |
| United States | Baptist Health Lexington | Lexington | Kentucky |
| United States | Saint Joseph Hospital East | Lexington | Kentucky |
| United States | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky |
| United States | University of Kentucky/Markey Cancer Center | Lexington | Kentucky |
| United States | Wake Forest University at Lexington | Lexington | North Carolina |
| United States | Cancer Center of Kansas-Liberal | Liberal | Kansas |
| United States | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii |
| United States | Nebraska Cancer Research Center | Lincoln | Nebraska |
| United States | Nebraska Hematology and Oncology | Lincoln | Nebraska |
| United States | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska |
| United States | Southeast Nebraska Cancer Center - 68th Street Place | Lincoln | Nebraska |
| United States | Littleton Adventist Hospital | Littleton | Colorado |
| United States | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado |
| United States | Hope Cancer Clinic | Livonia | Michigan |
| United States | Saint Mary Mercy Hospital | Livonia | Michigan |
| United States | Logan Regional Hospital | Logan | Utah |
| United States | Saint Joseph London | London | Kentucky |
| United States | The Dana-Farber Cancer Institute at Londonderry | Londonderry | New Hampshire |
| United States | Kaiser Permanente-Lone Tree | Lone Tree | Colorado |
| United States | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado |
| United States | Sky Ridge Medical Center | Lone Tree | Colorado |
| United States | UCHealth Lone Tree Health Center | Lone Tree | Colorado |
| United States | Monmouth Medical Center | Long Branch | New Jersey |
| United States | Longmont United Hospital | Longmont | Colorado |
| United States | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado |
| United States | PeaceHealth Saint John Medical Center | Longview | Washington |
| United States | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California |
| United States | Kaiser Permanente-Cadillac | Los Angeles | California |
| United States | Los Angeles County-USC Medical Center | Los Angeles | California |
| United States | USC / Norris Comprehensive Cancer Center | Los Angeles | California |
| United States | Baptist Health Louisville | Louisville | Kentucky |
| United States | Jewish Hospital | Louisville | Kentucky |
| United States | Jewish Hospital Medical Center Northeast | Louisville | Kentucky |
| United States | Saints Mary and Elizabeth Hospital | Louisville | Kentucky |
| United States | McKee Medical Center | Loveland | Colorado |
| United States | Medical Center of the Rockies | Loveland | Colorado |
| United States | Lowell General Hospital | Lowell | Massachusetts |
| United States | Texas Tech University Health Sciences Center-Lubbock | Lubbock | Texas |
| United States | UMC Cancer Center / UMC Health System | Lubbock | Texas |
| United States | Southeastern Regional Medical Center | Lumberton | North Carolina |
| United States | Virginia Mason Lynnwood Medical Center | Lynnwood | Washington |
| United States | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan |
| United States | Illinois CancerCare-Macomb | Macomb | Illinois |
| United States | Michigan Breast Specialists-Macomb Township | Macomb | Michigan |
| United States | Medical Center of Central Georgia | Macon | Georgia |
| United States | Dean Hematology and Oncology Clinic | Madison | Wisconsin |
| United States | University of Wisconsin Hospital and Clinics | Madison | Wisconsin |
| United States | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky |
| United States | Southern Ocean County Medical Center | Manahawkin | New Jersey |
| United States | Elliot Hospital | Manchester | New Hampshire |
| United States | Norris Cotton Cancer Center-Manchester | Manchester | New Hampshire |
| United States | Solinsky Center for Cancer Care | Manchester | New Hampshire |
| United States | Cancer Center of Kansas-Manhattan | Manhattan | Kansas |
| United States | Holy Family Memorial Hospital | Manitowoc | Wisconsin |
| United States | Mayo Clinic Health Systems-Mankato | Mankato | Minnesota |
| United States | OhioHealth Mansfield Hospital | Mansfield | Ohio |
| United States | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota |
| United States | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota |
| United States | Saint John's Hospital - Healtheast | Maplewood | Minnesota |
| United States | Marietta Memorial Hospital | Marietta | Ohio |
| United States | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin |
| United States | OhioHealth Marion General Hospital | Marion | Ohio |
| United States | Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan |
| United States | UP Health System Hematology Oncology Marquette | Marquette | Michigan |
| United States | UP Health System Marquette | Marquette | Michigan |
| United States | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa |
| United States | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin |
| United States | Contra Costa Regional Medical Center | Martinez | California |
| United States | WVUH-Berkely Medical Center | Martinsburg | West Virginia |
| United States | Sovah Health Martinsville | Martinsville | Virginia |
| United States | Fremont - Rideout Cancer Center | Marysville | California |
| United States | Mercy Medical Center - North Iowa | Mason City | Iowa |
| United States | Matthews Radiation Oncology Center | Matthews | North Carolina |
| United States | Novant Health Cancer Specialists-Matthews | Matthews | North Carolina |
| United States | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois |
| United States | ProMedica Maumee Cancer Center | Maumee | Ohio |
| United States | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio |
| United States | Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | Maumee | Ohio |
| United States | UH Seidman Cancer Center at Landerbrook Health Center | Mayfield Heights | Ohio |
| United States | UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania |
| United States | Kaiser Permanente Tysons Corner Medical Center | McLean | Virginia |
| United States | Cancer Center of Kansas - McPherson | McPherson | Kansas |
| United States | Holy Redeemer Hospital and Medical Center | Meadowbrook | Pennsylvania |
| United States | Cone Heath Cancer Center at Mebane | Mebane | North Carolina |
| United States | Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia |
| United States | Aspirus Medford Hospital | Medford | Wisconsin |
| United States | Riddle Memorial Hospital | Media | Pennsylvania |
| United States | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee |
| United States | Baptist Memorial Hospital for Women | Memphis | Tennessee |
| United States | Family Cancer Center-Memphis | Memphis | Tennessee |
| United States | Integrity Oncology PLLC-Memphis | Memphis | Tennessee |
| United States | UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio |
| United States | Ascension Columbia Saint Mary's Hospital Ozaukee | Mequon | Wisconsin |
| United States | Mercy UC Davis Cancer Center | Merced | California |
| United States | Idaho Urologic Institute-Meridian | Meridian | Idaho |
| United States | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho |
| United States | UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida |
| United States | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida |
| United States | Mount Sinai Medical Center | Miami Beach | Florida |
| United States | Woodland Cancer Care Center | Michigan City | Indiana |
| United States | UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio |
| United States | Dayton Physicians LLC-Signal Point | Middletown | Ohio |
| United States | Garnet Health Medical Center | Middletown | New York |
| United States | Middlesex Hospital | Middletown | Connecticut |
| United States | Mid-Michigan Medical Center - Midland | Midland | Michigan |
| United States | Bon Secours Saint Francis Medical Center | Midlothian | Virginia |
| United States | Dana-Farber/Brigham and Women's Cancer Center at Milford Regional | Milford | Massachusetts |
| United States | Ascension Columbia Saint Mary's Hospital - Milwaukee | Milwaukee | Wisconsin |
| United States | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin |
| United States | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin |
| United States | Aurora Sinai Medical Center | Milwaukee | Wisconsin |
| United States | Medical College of Wisconsin | Milwaukee | Wisconsin |
| United States | NYU Winthrop Hospital | Mineola | New York |
| United States | Abbott-Northwestern Hospital | Minneapolis | Minnesota |
| United States | Health Partners Inc | Minneapolis | Minnesota |
| United States | Hennepin County Medical Center | Minneapolis | Minnesota |
| United States | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin |
| United States | Trinity Cancer Care Center | Minot | North Dakota |
| United States | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana |
| United States | Community Medical Hospital | Missoula | Montana |
| United States | Saint Patrick Hospital - Community Hospital | Missoula | Montana |
| United States | Southern Cancer Center PC-Mobile | Mobile | Alabama |
| United States | Southern Cancer Center PC-Providence | Mobile | Alabama |
| United States | Southern Cancer Center PC-Springhill | Mobile | Alabama |
| United States | Kaiser Permanente-Modesto | Modesto | California |
| United States | Memorial Medical Center | Modesto | California |
| United States | Trinity Medical Center | Moline | Illinois |
| United States | Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana |
| United States | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan |
| United States | Monticello Cancer Center | Monticello | Minnesota |
| United States | UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon | Pennsylvania |
| United States | Franciscan Health Mooresville | Mooresville | Indiana |
| United States | Lake Norman Hematology Oncology Specialists-Mooresville | Mooresville | North Carolina |
| United States | Saint Claire Regional Medical Center | Morehead | Kentucky |
| United States | West Virginia University Healthcare | Morgantown | West Virginia |
| United States | Morristown Medical Center | Morristown | New Jersey |
| United States | Novant Health Oncology Specialists-Mount Airy | Mount Airy | North Carolina |
| United States | Wake Forest University at Mount Airy | Mount Airy | North Carolina |
| United States | McLaren Cancer Institute-Macomb | Mount Clemens | Michigan |
| United States | Virtua Memorial | Mount Holly | New Jersey |
| United States | McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan |
| United States | Good Samaritan Regional Health Center | Mount Vernon | Illinois |
| United States | Knox Community Hospital | Mount Vernon | Ohio |
| United States | Skagit Valley Hospital | Mount Vernon | Washington |
| United States | Skagit Valley Hospital Regional Cancer Care Center | Mount Vernon | Washington |
| United States | Palo Alto Medical Foundation-Camino Division | Mountain View | California |
| United States | Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View | California |
| United States | ProHealth D N Greenwald Center | Mukwonago | Wisconsin |
| United States | Inspira Medical Center Mullica Hill | Mullica Hill | New Jersey |
| United States | IU Health Ball Memorial Hospital | Muncie | Indiana |
| United States | The Community Hospital | Munster | Indiana |
| United States | Intermountain Medical Center | Murray | Utah |
| United States | Mercy Health Mercy Campus | Muskegon | Michigan |
| United States | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho |
| United States | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho |
| United States | Edward Hospital/Cancer Center | Naperville | Illinois |
| United States | Norris Cotton Cancer Center-Nashua | Nashua | New Hampshire |
| United States | Saint Joseph Hospital | Nashua | New Hampshire |
| United States | Meharry Medical College | Nashville | Tennessee |
| United States | Jersey Shore Medical Center | Neptune | New Jersey |
| United States | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi |
| United States | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey |
| United States | Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey |
| United States | Saint Peter's University Hospital | New Brunswick | New Jersey |
| United States | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut |
| United States | Yale University | New Haven | Connecticut |
| United States | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois |
| United States | Louisiana State University Health Science Center | New Orleans | Louisiana |
| United States | Ochsner Medical Center Jefferson | New Orleans | Louisiana |
| United States | Tulane University Health Sciences Center | New Orleans | Louisiana |
| United States | University Medical Center New Orleans | New Orleans | Louisiana |
| United States | Cancer Center of Western Wisconsin | New Richmond | Wisconsin |
| United States | New Ulm Medical Center | New Ulm | Minnesota |
| United States | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York |
| United States | Mount Sinai Hospital | New York | New York |
| United States | Mount Sinai Union Square | New York | New York |
| United States | Mount Sinai West | New York | New York |
| United States | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York |
| United States | NYP/Weill Cornell Medical Center | New York | New York |
| United States | Christiana Care Health System-Christiana Hospital | Newark | Delaware |
| United States | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware |
| United States | Helen F Graham Cancer Center | Newark | Delaware |
| United States | Licking Memorial Hospital | Newark | Ohio |
| United States | Medical Oncology Hematology Consultants PA | Newark | Delaware |
| United States | Newark Beth Israel Medical Center | Newark | New Jersey |
| United States | Newark Radiation Oncology | Newark | Ohio |
| United States | Providence Newberg Medical Center | Newberg | Oregon |
| United States | Chancellor Center for Oncology | Newburgh | Indiana |
| United States | Newport Hospital | Newport | Rhode Island |
| United States | USC Norris Oncology/Hematology-Newport Beach | Newport Beach | California |
| United States | Cancer Center of Kansas - Newton | Newton | Kansas |
| United States | Newton Medical Center | Newton | New Jersey |
| United States | Lakeland Hospital Niles | Niles | Michigan |
| United States | Faith Regional Health Services Carson Cancer Center | Norfolk | Nebraska |
| United States | Sentara Leigh Hospital | Norfolk | Virginia |
| United States | Sentara Norfolk General Hospital | Norfolk | Virginia |
| United States | Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut |
| United States | University of Kansas Cancer Center at North Kansas City Hospital | North Kansas City | Missouri |
| United States | Great Plains Health Callahan Cancer Center | North Platte | Nebraska |
| United States | Southwest VA Regional Cancer Center | Norton | Virginia |
| United States | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan |
| United States | Stephens Memorial Hospital | Norway | Maine |
| United States | Sutter Cancer Research Consortium | Novato | California |
| United States | Ascension Providence Hospitals - Novi | Novi | Michigan |
| United States | Henry Ford Medical Center-Columbus | Novi | Michigan |
| United States | Nyack Hospital | Nyack | New York |
| United States | Cancer Care Center of O'Fallon | O'Fallon | Illinois |
| United States | Advocate Christ Medical Center | Oak Lawn | Illinois |
| United States | Alta Bates Summit Medical Center - Summit Campus | Oakland | California |
| United States | Bay Area Tumor Institute | Oakland | California |
| United States | Kaiser Permanente-Oakland | Oakland | California |
| United States | TidalHealth Richard A Henson Cancer Institute | Ocean Pines | Maryland |
| United States | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin |
| United States | McKay-Dee Hospital Center | Ogden | Utah |
| United States | Ogden Regional Medical Center | Ogden | Utah |
| United States | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma |
| United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
| United States | Olathe Health Cancer Center | Olathe | Kansas |
| United States | MedStar Montgomery Medical Center | Olney | Maryland |
| United States | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska |
| United States | Alegent Health Immanuel Medical Center | Omaha | Nebraska |
| United States | Alegent Health Lakeside Hospital | Omaha | Nebraska |
| United States | Creighton University Medical Center | Omaha | Nebraska |
| United States | Hematology and Oncology Consultants PC | Omaha | Nebraska |
| United States | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska |
| United States | Nebraska Methodist Hospital | Omaha | Nebraska |
| United States | Oncology Hematology West PC | Omaha | Nebraska |
| * Note: There are 1452 locations in all - only the first 1000 are shown. | |||
| Lead Sponsor | Collaborator |
|---|---|
| Alliance for Clinical Trials in Oncology | Bayer, Canadian Cancer Trials Group, National Cancer Institute (NCI), United States Department of Defense |
United States, Canada, Guam, Puerto Rico,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Median Invasive Disease-free Survival (iDFS) | Invasive disease-free survival (iDFS), is defined as time from randomization to the first occurrence of any one of the following events for invasive disease: Distant recurrence, locoregional recurrence, ipsilateral or contralateral breast cancer, second primary (non-breast) invasive cancer or death from any cause. Censoring will occur on the date the patient was last known to be alive and free from all invasive breast cancer and second invasive primaries. | 5 years | |
| Secondary | Median Overall Survival (OS) | Overall survival (OS) is defined as the time from randomization to death from any cause; surviving patients will be censored at the date last known to be alive. | 5 years | |
| Secondary | Median Distant Disease Free Survival (DDFS) | DDFS is defined as the time from randomization to the first occurrence of any one of the following events for invasive disease: Distant recurrence, second primary (non-breast) invasive cancer or death from any cause; censoring will occur at the date the patient was last known to be alive and free from distant invasive breast cancer and second invasive primaries. | 5 years | |
| Secondary | Incidence of Cardiovascular Disease (Including Cerebrovascular Events, Myocardial Infarction, or Coronary Artery Disease Requiring Stent Placement, Angioplasty, or Bypass Surgery) | Up to 5 years | ||
| Secondary | Incidence of Toxicities, Graded Using the National Cancer Institute's Common Terminology Criteria for Adverse Events Version 4.3 | Up to 5 years |