Therapeutic Procedural Complication Clinical Trial
Official title:
Outcome and Risk Factors For Mortality in Peritoneal Dialysis Patients: 20 Years Experience in a Single Turkish Center
INTRODUCTION AND AIMS: The aims of this study were to evaluate patient and technique
survival rates, investigate peritonitis rates and evaluate factors affecting mortality in
peritoneal dialysis (PD) patients over a period of 20 years at Istanbul Faculty of Medicine
Peritoneal Dialysis Unit.
METHODS: Two hundred seventy seven patients have received PD as renal replacement therapy
(RRT) over a period of 20 years. After exclusion of patients with follow-up shorter than 3
months and patients whose data were not available, 250 patients were examined
retrospectively. Data for sex, age, primary disease, comorbidities, follow up duration,
cause of death, and cause of technique failure were collected from medical records.
Material and Method All patients 18 years of age and older who were treated with PD at the
Istanbul Medical Faculty from October 1994 to October 2014 were included in the study.
Patients exclude which follow-up shorter than 3 months and patients whose data were not
available. From the day PD was started, all peritonitis data were collected prospectively in
a large database. The data include Socio-demographic data, type of peritoneal dialysis,
starting time and duration of every peritonitis episode, causative organisms and outcome of
the peritonitis, which could be cure, change of PD catheter, transfer to hemodialysis, or
death. The time in months from PD start to the first episode of peritonitis was computed.
Primary kidney disease was classified into 9 main categories according to the codes of the
European Renal Association - European Dialysis and Transplant Association. Peritonitis in PD
was defined as a peritoneal dialysate effluent containing >100 white blood cells/mL, of
which >50% were polymorphonuclear leukocytes. Patients with two or more pathogens isolated
from the cultures in a peritonitis episode were considered to have polymicrobial
peritonitis. A relapse of peritonitis was defined when the same organism or a
culture-negative peritonitis episode was identified within 4 weeks of completing appropriate
antibiotic therapy for a previous episode.
Socio-demographic, clinical and treatment characteristics, medium (standard deviation for
continuous variables) or median (25th and 75th percentages); number for categorical
variables (rate) were calculated. Cox regression analysis applied to examine the impact of
demographic and clinical features of periton dialysis patients . Chi-square test for
categorical variables used. Univariate and multivariate analyzes calculated using the
Kruskal-Wallis or Mann-Whitney test method. P-value was <0.05 for as long as it is
considered statistically significant. The evaluation of the results obtained using SPSS 21.0
software.
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Observational Model: Ecologic or Community, Time Perspective: Retrospective
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