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Anesthetics to Prevent Lung Injury in Cardiac Surgery — APLICS  

Postoperative Pulmonary Complications Clinical Trial

Official title:
Anesthetics to Prevent Lung Injury in Cardiac Surgery

Clinical Trial Summary

The purpose of this study is to investigate whether the use of inhaled anesthetics, compared to intravenous anesthetics, can affect the amount of lung inflammation and postoperative respiratory complications seen after cardiac surgery.

Clinical Trial Description

Randomized, controlled trial involving 45 adult patients undergoing cardiac surgery with cardiopulmonary bypass. Patients will be randomized to receive either inhaled anesthesia with sevoflurane or total intravenous anesthesia (TIVA) with propofol for the maintenance phase of their cardiac anesthetic. Assessment of lung inflammation will take place using fiberoptic bronchoscopic sampling of lung fluid as well as serum collection before and after exposure to cardiopulmonary bypass, and the incidence of compositive postoperative pulmonary complications will take place in the postoperative period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02918877
Study type Interventional
Source Beth Israel Deaconess Medical Center
Contact
Status Completed
Phase Phase 1/Phase 2
Start date June 9, 2017
Completion date February 1, 2021
View Details
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