Input of a Multidisciplinary Device to Accompany the Announce of Diagnosis for Young Children With Serious Constitutional Hemorrhagic Disease and Their Families

Other Constitutional Bleeding Disorders Clinical Trial

— ACADHEM  

Official title:

Input of a Multidisciplinary Device Including a Psychological Approach, to Accompany the Announce of Diagnosis for Young Children With Serious Constitutional Hemorrhagic Disease and Their Families

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02834130
• Other study ID #: 2014-05
• Secondary ID: 2014-A00367-40
• Status: Completed
• Phase: N/A
• First received: October 21, 2015
• Last updated: July 18, 2016
• Start date: April 2014

Study information

• Verified date: July 2016
• Source: Assistance Publique Hopitaux De Marseille
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Agence Nationale de Sécurité du Médicament et des produits de santé
• Study type: Interventional

Clinical Trial Summary

Severe forms of hemophilia and other constitutional bleeding disorders represent a group of rare diseases. In last decades, news therapies have dramatically increased life expectancy and joint's protection.

The investigators propose to set up a single-centre, descriptive, transversal pilot study, designed for the inclusion of around thirty children from 2 to 10 years, with haemophilia or allied hereditary bleeding disorders (HBD), who were referred to the Hemophilia Treatment Center (HTC) of Marseille at diagnosis. For those children who were able to benefit from the totality or part of the device accompanying the diagnostic announcement in the past 10 years.

Description:

Severe forms of hemophilia and other constitutional bleeding disorders represent a group of rare diseases. In last decades, news therapies have dramatically increased life expectancy and joint's protection. The recurrence of joint bleedings is responsive of multifocal arthropathy in the natural history, but nowadays, the orthopedic outcome is good thanks to prophylactic treatments.

However, the announcement of the diagnosis of such hereditary bleeding disorders at a very young age represents a real psychological trauma for parents. Such an announcement may induce some psycho-developmental impairment.

An innovative support has been implemented at the Hemophilia Treatment Center in Marseille, in conjunction with the French Hemophilia Society. This program is based on a multidisciplinary partnership that favors the psychological support and the reinsurance of the parents.

With Rare Diseases Foundation support, the investigators have initiated this pilot study that will include more than 20 patients with severe hemophilia or constitutional bleeding disorder, who benefit from the device. This descriptive, monocentric, interventional study will permit to describe the psychological status, the quality of life of patients and their parents, but also to evaluate the impact of the device on initiation and observance of treatments like Long Term Prophylaxis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. primary completion date: April 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 3 Years to 12 Years

Eligibility

Inclusion Criteria:

• Patients aged between 3 and 12 years

• Patients diagnosed and treated at the Center until inclusion

• Patients with FVIII :C < 2% or with FIX :C <2% or with FVII:C <2% or with FXIII:C <2% or fibrinogen <0,2 g/l, or with type 3 von Willebrand diseases or Thrombasthenia of Glanzmann diseases.

• Patient who participate to multidisciplinary support and announcement of diagnosis device

• Voluntarily given fully informed written and signed consents obtained before any study-related procedures are conducted

Exclusion Criteria:

• Patient with other clotting disorder or disease.

• Patient diagnosed or treated in other centre

• Patient with psychiatric disorder or disease

• Patient with other severe chronic disease

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Blood Coagulation Disorders
• Hemorrhagic Disorders
• Hemostatic Disorders
• Other Constitutional Bleeding Disorders
• Severe Forms of Hemophilia

Intervention

Behavioral:
• Evaluation of psychological and psychopathological

Locations

Country	Name	City	State
France	Hopital Enfants de la Timone Assistance Publique Hôpitaux de Marseille	Marseille

Sponsors (1)

Lead Sponsor	Collaborator
Assistance Publique Hopitaux De Marseille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of Treatment Exposure Days compared to the Number of Treatment Exposure days prescribed	Treatment Observance	2 years	No
Secondary	Assessment of patient's behavioral condition using the Child Behavior Check-list (CBCL) 1,5-5		2 Years	No
Secondary	Assessment of the patient's body consciousness through the "CORP-R" test (french test of body mapping)		2 years	No
Secondary	Assessment of patient's quality of life using the "Kidscreen" questionnaire for children		2 years	No
Secondary	Assessment of the patient's parents' Qaulity of life through the Short Form Health Survey (SF-36)		2 Years	No