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Clinical Trial Summary

This study aims to assess the impact of NC balloon post-dilatation on coronary microcirculation in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).


Clinical Trial Description

Suboptimal stent deployment can lead to future stent failure. Thus, optimising stent deployment with non-compliant balloons (NC balloon) post dilatation (PD) at high pressures is an established strategy. In the context of ST segment elevation myocardial infarction (STEMI), PD has been correlated anecdotally with the no reflow phenomenon. This study aims to determine the impact of stent post-dilation (PD) with NC balloons at high pressures on coronary microcirculation during PPCI by measuring the index of microcirculatory resistance (IMR) pre and post stent post-dilatation. Pre and post PD, an optical coherence tomography (OCT) study will be performed to assess stent deployment and identify parameters that predict the changes in IMR. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02788396
Study type Observational
Source Mid and South Essex NHS Foundation Trust
Contact
Status Completed
Phase
Start date May 1, 2016
Completion date May 31, 2018

See also
  Status Clinical Trial Phase
Active, not recruiting NCT02601781 - Use of BVS in ST-segment Elevation Myocardial Infarction (STEMI): the BVS STEMI STRATEGY-IT Prospective Registry Phase 4
Completed NCT01747174 - REperfusion Facilitated by LOcal Adjunctive Therapy in ST-elevation Myocardial Infarction Phase 2
Active, not recruiting NCT01665365 - Long-term Clinical Outcome in Patients Undergoing Remote Ischemic Conditioning Before Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction: a Follow-up Study N/A
Recruiting NCT04825743 - A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI Phase 3