Acute ST-elevation Myocardial Infarction Clinical Trial
Thirty patients with acute ST-elevation myocardial infarction treated with primary PCI and aspiration of thrombus material from the infarct related coronary artery will be included. Both cellular and non cellular content of the thrombus will be examined with morphological and immunohistochemical methods and related to time from onset of symptoms to PCI, as well as to the degree of myocardial necrosis. Furthermore, mRNA expression of selected signal molecules will be performed. In addition, peripheral venous blood samples will be drawn and analyzed for signalling molecules and corresponding mRNA expression in circulating leukocytes.
Observational, cross-sectional study on 30 patients with STEMI treated with thrombectomy and
PCI with stent implantation. Composition and characteristics of the coronary thrombi with
respect to cell types, genetic expression and presence of specific markers of inflammation,
platelet activity, endothelial activation, coagulation and fibrinolysis will be investigated
in relation to the levels of these markers in the general circulation, and specifically
related to the time axis from symptom to PCI, as well as to the degree of myocardial
necrosis.
Intracoronary thrombus will be retrieved by standard aspiration catheter, washed with saline
and stored on formalin as advised by the Department of pathology, OUS Ullevål. A specific
protocol for morphological and immunohistochemical methods is prepared and has been shown
suitable in a pilot study on 5 patients. Assessment of coronary TIMI flow and peripheral
blush grade after thrombus aspiration and PCI will be done. At the same time, peripheral
venous blood will be drawn, processed and stored at -80˚C for later analyses. Demographic
variables will be recorded.
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