Painful Osteoarthritis of the Knee Clinical Trial
Official title:
Analgesic Effect and Functional Improvement Caused by Radiofrequency Ablation of Genicular Nerves in Patients With Advanced Osteoarthrosis of the Knee Joint Until 1 Year Following Treatment
Pharmacological treatment of pain due to osteoarthritis of the knee often proves to be
inadequate and/or cause intolerable side effects. Arthroplasty of the knee may offer a
solution, but waiting lists may be long or certain patients may not be apt for a surgical
intervention. Therefore an alternative pain treatment that is effective and has little side
effects allowing to offer pain relief to those difficult to manage patients would be an
added value in the therapeutic options.
We studies the short and long-term effects of radio frequency treatment of the genicular
nerves in patients with severe pain due to osteoarthritis of the knee.
Radio frequency treatment (RF) of the genicular nerves was found to be effective in a
randomized controlled trial. Because of the blinding patients were allowed to continue
pre-intervention pharmacological treatment, which may have interfered with the outcome. The
short follow-up (12 weeks) does not allow drawing conclusion on the duration of the effect.
We aimed at assessing the pain reducing effect of RF of the genicular nerves and the
duration of the effect.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04675034 -
A Study of the Efficacy and Safety of MEDI7352 in Subjects With Painful Osteoarthritis of the Knee
|
Phase 2 | |
| Completed |
NCT04770428 -
Evaluate Safety, Tolerability, Pharmacokinetics and Immunogenicity of MEDI7352 in Healthy Volunteers
|
Phase 1 |