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The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes

Preterm Premature Rupture of Membranes Clinical Trial

Official title:
The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes

Clinical Trial Summary

To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.

Clinical Trial Description

The micronutrient vitamin C is an effective water soluble antioxidant that scavenges several reactive oxygen species, thus reducing oxidative stress, It also acts as an enzymatic cofactor to the enzymes lysyl hydroxylase and prolyl hydroxylase, which is required for synthesis of hydroxyproline and hydroxylysine, Collagen requires hydroxyproline bridges across the triple helix to provide stability to it, Ascorbic acid also causes down regulation of the metalloproteinase-2 and biosynthesis of collagen where it is required for the formation of triple helical structure of collagen. Thus, ascorbic acid participates in the equilibrium between synthesis and degradation of collagen and this may be critical in reducing the occurrence of preterm PROM. ;

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02635451
Study type Observational
Source Ain Shams Maternity Hospital
Contact Mohamed Hu Mostafa, MD
Phone 01003993165
Email magicmostwanted@yahoo.com
Status Not yet recruiting
Phase N/A
Start date January 2016
Completion date July 2016
View Details
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Completed NCT02702297 - Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes
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Active, not recruiting NCT04532021 - Matrix Metalloproteinase 14, Neopterin, and Orosomucoid 1 Levels in PPROM
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Recruiting NCT01584323 - Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes N/A
Recruiting NCT00466128 - Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Phase 2
Terminated NCT00463736 - Magnesium Sulfate Versus Placebo for Tocolysis in PPROM N/A