Comparison of Two Different Techniques of Synovial Biopsy and Resistances of Cutaneous Smears in Suspected PPI — COSPI  

Infection of Total Knee Joint Prosthesis Clinical Trial

Official title: Comparison of Directed Versus Undirected Synovial Biopsy in Culture-negative Periprosthetic Joint Infections (With Preoperative Smears From the Skin) of the Knee and Evaluation of Outcome After Revision Joint Arthroplasty

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine whether an undirected synovial biopsy technique has the same accuracy in detecting periprosthetic joint infection in the knee as an arthroscopic assisted directed synovial biopsy technique.

Clinical Trial Description

Successful treatment of an infected joint arthroplasty depends on correctly identifying the responsible pathogens. The value of a preoperative biopsy remains controversial. We compared the sensitivity and specificity of two techniques of synovial biopsy of knee joint arthroplasties suspicious for infection and asked whether the results correlate with intraoperative findings at revision. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Infection
• Infection of Total Knee Joint Prosthesis

• NCT number: NCT02594930
• Study type: Interventional
• Source: Technische Universität München
• Contact: Norbert Harrasser, Dr.
• Phone: 00498941405229
• Email: norbert.harrasser@gmx.net
• Status: Recruiting
• Phase: N/A
• Start date: September 2015
• Completion date: November 2017