Irritable Bowel Syndrome With Constipation Clinical Trial
Official title:
A Phase 2b, Randomized, Double-blind, Double-dummy, Placebo-controlled, Parallel-group, Dose-range-finding Study of Two Delayed Release Formulations of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation
The objectives of this study are to evaluate the safety, efficacy, and dose response of two delayed release formulations of linaclotide (DR; DR formulation 1 is DR1; DR formulation 2 is DR2) administered orally to patients with irritable bowel syndrome with constipation (IBS-C). Additional objectives include understanding how the two DR formulations compare with each other and with the FDA-approved 290 μg LINZESS® (the immediate release [IR] formulation of linaclotide).
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00730171 -
An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation
|
Phase 3 | |
Completed |
NCT00215566 -
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of DDP733 for IBS-c
|
Phase 2 | |
Completed |
NCT00765999 -
An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation
|
Phase 3 | |
Recruiting |
NCT05646186 -
Personalized Dietary Intervention Based on Microbiome Analysis vs FODMAP Diet for Irritable Bowel Syndrome
|
N/A | |
Completed |
NCT04026113 -
Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)
|
Phase 3 | |
Recruiting |
NCT05519683 -
Home Transcutaneous Electrical Acustimulation (TEA)
|
Phase 2/Phase 3 | |
Active, not recruiting |
NCT04166058 -
Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C
|
Phase 3 | |
Completed |
NCT04968652 -
IBS-C Questionnaire Study
|
||
Completed |
NCT05164861 -
Safety and Efficacy of Non-alcoholic Beverage Based on Kombucha in Patients With Constipations
|
N/A | |
Completed |
NCT02590432 -
An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation
|
Phase 4 | |
Terminated |
NCT02559817 -
A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation
|
Phase 2 | |
Recruiting |
NCT05796388 -
A Study of Virtual Reality and Linaclotide for IBS-C
|
N/A | |
Completed |
NCT00380250 -
Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation
|
Phase 3 | |
Completed |
NCT04647045 -
An Evaluation of Cultured Milk Drink on Immune Status of Patients With Irritable Bowel Syndrome: Constipation Predominant
|
N/A | |
Completed |
NCT03054506 -
The Effect of CSP01 on Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation
|
N/A | |
Recruiting |
NCT04214470 -
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in IBS
|
||
Not yet recruiting |
NCT06219707 -
Electro-acupuncture for Irritable Bowel Syndrome With Constipation
|
N/A | |
Recruiting |
NCT03596905 -
Efficacy and Safety of Plecanatide in Children 6 to <18 Years of Age With Irritable Bowel Syndrome With Constipation (IBS-C)
|
Phase 2 | |
Completed |
NCT04132804 -
Effect of Tai Chi as Treatment for IBS-C
|
N/A | |
Completed |
NCT00938717 -
Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
|
Phase 3 |