Clinical Trials Logo
  1. Home
  2. Other
  3. NCT02333669

Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome

Neonatal Respiratory Distress Syndrome Clinical Trial

Official title:
Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome

Clinical Trial Summary

Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells. Increasing evidence has demonstrated that these lung disorders might be an important cause of neonatal respiratory distress syndrome (NRDS) by influencing gas exchange or surfactant function, particularly in near-term and term infants. The SCNN1A gene, which encodes the α-ENaC, might predispose infants to NRDS. To explore whether the single-nucleotide polymorphisms (SNPs) of SCNN1A are associated with NRDS, we conducted a case-control study to investigate the NRDS-associated loci in Han Chinese infants. Seven target SNPs were selected from the SCNN1A gene and were genotyped using the improved multiplex ligase detection reaction (iMLDR).

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02333669
Study type Observational
Source Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Contact
Status Completed
Phase N/A
Start date January 2012
Completion date December 2014
View Details
See also
  Status Clinical Trial Phase
Completed NCT02522455 - Flow-cycled Ventilation in Preterm Infants N/A
Not yet recruiting NCT04019886 - Impact of Neurophysiological Facilitation of Respiration in Preterm Neonates N/A
Terminated NCT02999165 - Breastfeeding Infants Receiving Respiratory Support Trial
Completed NCT02112513 - The Use of Maternal Serum Unconjugated Estriol for Monitoring the Prevention of Neonatal Respiratory Distress Syndrome
Completed NCT02824497 - Early Neonatal Respiratory Distress: Changes in Level IIb Hospital Over a Period of One Year
Completed NCT04000568 - Breathing Variability and NAVA in Neonates
Completed NCT01926106 - Nasal Intermittent Positive-Pressure Ventilation for Twin Infants With Respiratory Distress Syndrome N/A
Completed NCT02819050 - Effective Approaches & Strategies to Ease Off Nasal CPAP In Preterm Infants N/A
Completed NCT02041676 - Chest Physiotherapy Technique Increasing Inspiratory Flow on Weaning From Non Invasive Ventilation N/A
Recruiting NCT04409665 - The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST) Phase 1
Completed NCT03446937 - Effect of Antenatal Corticosteroids on Neonatal Morbidity. N/A
Terminated NCT03235986 - A Study To InvestigateThe Safety, Tolerability And Efficacy Of Nebulised Curosurf® In Preterm Neonates With Respiratory Distress Syndrome (RDS) Phase 2
Recruiting NCT06367881 - Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS Phase 1