To Examine Whether or Not the Primary Causes of OA or RA Might be Bone Alterations

Osteoarthritis of Multiple Joints Clinical Trial

Official title:

The Examinations Whether or Not the Primary Causes of Osteoarthritis or Rheumatoid Arthritis in Joints Might be Bone Alterations

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02327650
• Other study ID #: OA RA Bone Study
• Status: Recruiting
• Start date: November 2015
• Est. completion date: December 2024

Study information

• Verified date: September 2021
• Source: Shinshu University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Generally, osteoarthris (OA) is considered as primarily cartilage disease. However, as we and others have previously reported, a portion of OA might be caused primarily by bone alterations. In this study, we prospectively and retrospectively show that the bone altertations may affect OA primarily in all of the joints.

In addition, rheumatoid arthritis (RA) is a joint disease when immune system attacks synovium. Joint destruction occurrs continuously if suitable treatment is not performed. The etiology of RA is still largely unknown. As with OA, RA can be primarily damaged in bone, instead of cartilage. Here we prospectively and retrospectively show that the bone altertations may affect RA primarily in all of the joints.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: December 2024
• Est. primary completion date: April 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• RA and/or OA

Exclusion Criteria:

• N/A

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Osteoarthritis
• Osteoarthritis of Multiple Joints
• Progression of Rheumatoid Arthritis

Intervention

Procedure:
• The examinations for bones in joints of OA and RA patients

Locations

Country	Name	City	State
Japan	Yukio Nakamura	Matsumoto	Nagano
Japan	Yukio Nakamura	Matsumoto

Sponsors (1)

Lead Sponsor	Collaborator
Shinshu University

Country where clinical trial is conducted

Japan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The bone signal changes detected by MRI in OA and/or RA patients		1 year