The Effect of Pomegranate on Aging and Inflammation of the Skin

Skin Photoaging, Inflammation and Skin Pathogenic Bacteria Clinical Trial

— PomSkin  

Official title:

Clinical Trial to Determine the Efficacy of Pomegranate for Skin Inflammation and Aging

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02258776
• Other study ID #: PomSkin 14-001011
• Status: Completed
• Phase: N/A
• First received: September 26, 2014
• Last updated: February 27, 2017
• Start date: October 2015
• Est. completion date: February 27, 2017

Study information

• Verified date: February 2017
• Source: University of California, Los Angeles
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the efficacy of pomegranate extract and pomegranate juice on skin inflammation and aging. The information gained from this study may lead to the development of a pomegranate product that can decrease the effects of aging, inflammation and harmful bacteria on the skin.

In this study, two pomegranate products (extract and juice) will be compared with a placebo, a study product that looks like pomegranate extract, but contains no active ingredients.

Description:

Pomegranate (Punica granatum L.) is grown commercially in the Near East, India, Spain, Israel and the United States (California) where it is of significant economic importance1. Pomegranate fruits and products, including juice, tea, wine and extracts are widely consumed and recognized for their health benefits. Pomegranate (Punica granatum L.) fruit possesses strong antioxidant, anti-inflammatory and antiproliferative properties. In recent years, most health advantages of pomegranate have been attributed to the presence of ellagitannins, mainly punicalagins and ellagic acid. Punicalagin is unique to pomegranate and is part of a family of ellagitannins. The ellagitannins are hydrolyzed to ellagic acid in the gut, and further metabolized by the colon microflora to form urolith A and B. Investigations using pure bacterial cultures have shown that pomegranate by-products and punicalagins significantly inhibited the growth of pathogenic Escherichia coli, Pseudomonas aeruginosa, clostridia and Staphylococcus aureus.

Oral feeding of pomegranate fruit extract to mice afforded protection to mouse skin against the adverse effects of ultraviolet-B (UVB) radiation by modulating UVB-induced signaling pathways.5 Hydroalcoholic extract based-ointment from pomegranate was reported improving wound healing in vivo. Pomegranate ellagitannins have been demonstrated to have antimicrobial activity. Punicalagin is unique to pomegranate and is part of a family of ellagitannins. The ellagitannins are hydrolyzed to ellagic acid in the gut, and further metabolized by the colon microflora to form urolith A and B. Investigations using pure bacterial cultures have shown that pomegranate by-products and punicalagins significantly inhibited the growth of pathogenic Escherichia coli, Pseudomonas aeruginosa, clostridia and Staphylococcus aureus.

Pomegranate Extract (POMx) is made from pomegranate fruit as a byproduct of pomegranate juice (PJ) production. A second pressing of the fruit liberates a complex mixture of hydrolysable polyphenolic compounds normally ingested with pomegranate juice, and these are purified by spray drying. POMx powder is encapsulated for oral administration, with each capsule containing 1,000 mg of pomegranate polyphenols. The present study will determine whether a pomegranate product (POMx or PJ) can decrease skin photoaging, inflammation and skin pathogenic bacteria.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 75
• Est. completion date: February 27, 2017
• Est. primary completion date: February 27, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 30 Years to 45 Years

Eligibility

Inclusion Criteria:

1. Age 30-45 years or older, female and any racial/ethnic group

2. Subjects must understand and sign the informed consent prior to participation

3. Subjects must be in generally good health

4. Subjects must be able and willing to comply with the requirements of the protocol.

Exclusion Criteria:

1. Oral or topical retinoid use within twelve months of entry into the study

2. Non-compliant subjects

3. Taking any antibiotics or other medication or dietary supplements regularly

4. Subjects with a significant medical history or concurrent condition that the investigator(s) feel is not safe for the study

5. Subjects who cannot avoid excessive exposure to either natural or artificial sunlight.

6. Allergic to pomegranate products

Related Conditions & MeSH terms

• Inflammation
• Skin Photoaging, Inflammation and Skin Pathogenic Bacteria

Intervention

Dietary Supplement:
• Pomegranate Extract
Pomegranate extract 1000mg will be taken 1/day for 12 weeks.
• Pomegranate Juice
Pomegranate juice 8oz will be consumed 1/day for 12 weeks.
• Placebo
Placebo will be taken 1/day for 12 weeks.

Locations

Country	Name	City	State
United States	UCLA Center for Human Nutrition	Los Angeles	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, Los Angeles

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in inflammatory markers between pomegranate extract and pomegranate juice versus placebo.	Utilization of a two-sample t-test to compare the change in between the three groups	Baseline and 12 weeks
Secondary	Linear mixed effects models to evaluate effect of treatment of time trends and demographic covariates	Correlation between outcomes measures (e.g. between acne lesion count and skin microbiota) with mixed effects models	Baseline and 12 weeks