Pregnancy Clinical Trial
Official title:
Analysis of Serum Pancreatic Stone Protein (PSP) in Healthy Pregnant Women and Its Value in Predicting Inflammatory Complications During Pregnancy
This prospective, single centred cohort study evaluates the physiological course of the potentially novel biomarker PSP in pregnant women as well as its predictive role in the development of inflammatory complications during pregnancy.
Pregnant women feature a complex immunological condition caused by pregnancy itself and hence
women present with an increased susceptibility to some infectious and non-infectious
inflammatory diseases. Specifically regulated mechanisms have been described occurring in
normal whereas lacking in pathological pregnancies in both the native and adaptive immune
system in animal models and humans. However, clinically relevant biomarker associated with
preterm premature rupture of membranes (PPROM), amniotic infection syndrome (AIS) as well as
pregnancy associated complications such as preeclampsia and hemolysis, elevated liver
enzymes, and low platelets (HELLP) syndrome have their limitations.
Pancreatic stone protein (PSP), originally obtained from human pancreatic stones from
patients operated for chronic calcifying pancreatitis, has been studied in several
gastrointestinal pathologies.
The aim of this study is to evaluate the physiological course of the potentially novel
biomarker PSP in pregnant women as well as to assess its predictive role in the development
of inflammatory complications during pregnancy.
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