ST-segment Elevation Myocardial Infarction (STEMI) Clinical Trial
Official title:
Effect of Remote Ischaemic Conditioning in STEMI Patients Treated by thromboLYSIS: A Randomised Controlled Clinical Trial (the ERIC-LYSIS Study)
New treatments are required to improve health outcomes in patients with ischemic heart
disease. This is especially so in developing countries such as Mauritius in which optimal
therapy for acute myocardial infarction may not be widely available. For example for
patients presenting with a heart attack (caused by a blockage in one of the heart blood
vessels) the treatment of choice would be to remove the blockage by primary percutaneous
coronary intervention (PCI) using an angioplasty balloon and put a stent (a spring-like
structure) to keep the artery opened. However, PCI is not widely available in Mauritius and
heart attack patients are given clot-busting therapy to remove the blockage, but this is not
as effective as PCI.
Therefore, in this research study we investigate a new cheap treatment that may help protect
the heart against damage during a heart attack, called remote ischemic conditioning (RIC),
in which a blood pressure cuff is placed on the upper arm and inflated for 5 minute and
deflated for 5 minutes a cycle which is repeated 4 times in total in patients presenting
with a heart attack. By temporarily depriving oxygen and nutrients to the arm with the blood
pressure cuff a protective signal can be relayed to the heart to reduce the amount of damage
occurring during the heart attack and thereby prevent the onset of heart failure.
Study hypothesis: Remote ischaemic conditioning will reduce the amount of damage occurring
to the heart muscle during a heart attack..
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