ST-elevation Myocardial Infarction Clinical Trial
— LIPSIA-CONDOfficial title:
Effect of Conditioning on Myocardial Damage in ST-elevation Myocardial Infarction - Comparison of Combined Intrahospital Preconditioning Plus Postconditioning Versus Postconditioning Versus Control.
Verified date | December 2014 |
Source | University of Leipzig |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The LIPSIA-Conditioning trial is an investigater initiated, randomized, single-center study
that will assess the effect of different intrahospital conditioning protocols on myocardial
damage assessed by MRI in patients with acute ST-elevation myocardial infarction.
The following groups will be compared:
1. Combined intrahospital pre- plus postconditioning versus
2. Postconditioning versus
3. Control
Status | Completed |
Enrollment | 600 |
Est. completion date | September 2014 |
Est. primary completion date | August 2014 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: ST-elevation myocardial infarction <12 hours Exclusion Criteria: - Age = 18 years - Patients presenting with pregnancy - Thrombolysis <12 hours - Patients without informed consent - Participation in another trial. |
Country | Name | City | State |
---|---|---|---|
Germany | University Leipzig - Heart Center, Department of Cardiology | Leipzig | Please Select |
Lead Sponsor | Collaborator |
---|---|
University of Leipzig |
Germany,
Bøtker HE, Kharbanda R, Schmidt MR, Bøttcher M, Kaltoft AK, Terkelsen CJ, Munk K, Andersen NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sørensen HT, Redington AN, Nielsen TT. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet. 2010 Feb 27;375(9716):727-34. doi: 10.1016/S0140-6736(09)62001-8. — View Citation
Lønborg J, Kelbaek H, Vejlstrup N, Jørgensen E, Helqvist S, Saunamäki K, Clemmensen P, Holmvang L, Treiman M, Jensen JS, Engstrøm T. Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Circ Cardiovasc Interv. 2010 Feb 1;3(1):34-41. doi: 10.1161/CIRCINTERVENTIONS.109.905521. Epub 2010 Jan 26. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Infarct size assessed by MRI | 1 week after infarction | ||
Other | Microvascular obstruction assessed by MRI | 1 week after infarction | ||
Primary | Myocardial salvage assessed by MRI | 1 week after infarction | ||
Secondary | Composite of death, reinfarction and readmission for congestive heart failure | 6 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01864343 -
Target Temperature Management In Myocardial Infarction - A Pilot Study
|
N/A | |
Completed |
NCT00962416 -
Comparison of Biomatrix Versus Gazelle in ST-Elevation Myocardial Infarction (STEMI)
|
Phase 4 | |
Active, not recruiting |
NCT00927615 -
Comparison of Intracoronary Versus Intravenous Abciximab in ST-segment Elevation Myocardial Infarction (CICERO)
|
N/A | |
Completed |
NCT03135275 -
MULTivessel Immediate Versus STAged RevaScularization in Acute Myocardial Infarction -The MULTISTARS AMI Trial
|
N/A | |
Recruiting |
NCT02592694 -
Intracoronary Cocktail Injection Combined With Thrombus Aspiration in STEMI Patients Treated With Primary Angioplasty
|
Phase 4 | |
Withdrawn |
NCT01991366 -
Should Integrilin be an Integral Part of Adjunctive Therapy in Patients Undergoing Primary PCI for ST-Elevation MI?
|
||
Completed |
NCT01197729 -
OPTAMI (Optimized Therapy of Acute Myocardial Infarction) - Registry
|
N/A | |
Completed |
NCT06426537 -
Colchicine's Efficacy in MI Patients: Comparing PCI and Non-Reperfusion Approaches
|
Early Phase 1 | |
Completed |
NCT01882179 -
Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size
|
Phase 3 | |
Terminated |
NCT00719914 -
A Safety/Efficacy Study of Intracoronary Integrilin to Improve Balloon Angioplasty Outcomes for the Treatment of Heart Attacks
|
Phase 2 | |
Completed |
NCT00952224 -
Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance - Impact on Outcome
|
N/A | |
Completed |
NCT00378391 -
European Registry on STEMI Patients Transferred for PCI With Upstream Use of Abciximab - EuroTransfer Registry
|
N/A | |
Withdrawn |
NCT04303377 -
Early Treatment With Evolocumab in Patients With ST-elevation Myocardial Infarction
|
Phase 2 | |
Completed |
NCT03523624 -
Factor XIII and Other Biomarkers in ST Segment Elevation Myocardial Infarction
|
||
Completed |
NCT01531114 -
PraSugrel vs TicagrElor in ST-Elevation Myocardial Infarction paTients With Diabetes Mellitus
|
Phase 3 | |
Active, not recruiting |
NCT01960933 -
Primary PCI in Patients With ST-elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization
|
N/A | |
Completed |
NCT00502528 -
Endothelin Receptor Blockade in Acute ST-elevation Myocardial Infarction
|
Phase 2 | |
Recruiting |
NCT02062554 -
Brasilia Heart Study
|
||
Recruiting |
NCT04150016 -
In-stent Repair and Vessel Reaction of STEMI Patients With OCT
|
N/A | |
Recruiting |
NCT03074214 -
Prognostic Value of Copeptin for Infarct Size and Prognosis in Patients With ST-elevation Myocardial Infarction
|
N/A |