ST-elevation Myocardial Infarction Clinical Trial
Official title:
Effect of Conditioning on Myocardial Damage in ST-elevation Myocardial Infarction - Comparison of Combined Intrahospital Preconditioning Plus Postconditioning Versus Postconditioning Versus Control.
The LIPSIA-Conditioning trial is an investigater initiated, randomized, single-center study
that will assess the effect of different intrahospital conditioning protocols on myocardial
damage assessed by MRI in patients with acute ST-elevation myocardial infarction.
The following groups will be compared:
1. Combined intrahospital pre- plus postconditioning versus
2. Postconditioning versus
3. Control
Rapid reperfusion of the infarct-related coronary artery is essential to salvage ischemic
myocardium in patients with acute ST-elevation myocardial infarction (STEMI). Paradoxically,
restoration of the blood flow to the ischemic area may result in further injury to the
myocardium.
This phenomenon is described as 'ischemia/reperfusion injury' and the pathophysiological
mechanisms are not fully elucidated. A cardioprotective effect of ischemic preconditioning as
well for postconditioning (short repetitive cycles of reperfusion and re-occlusion) has been
demonstrated in experimental studies and in pilot studies on patients with acute STEMI
treated with primary percutaneous coronary intervention.
Aim of this study is to compare for the first time the combination of intrahospital pre- and
postconditioning versus exclusive postconditioning versus control. The primary endpoint of
this study will be the salvaged area at risk assessed by cardiac magnetic resonance imaging.
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