Chronic Respiratory Failure With Acute Decompensation Requiring Mechanical Ventilation for More Than 48 Hours Clinical Trial
Official title:
Effects of Chair Sitting Exercise Intervention on Weaning From Mechanical Ventilation and Mortality of Critically Ill Patients With Acute Respiratory Failure: a Randomised Controlled Trial.
The occurrence of an acute respiratory failure necessitates mostly admission to ICU and
mechanical ventilation (MV). Rapid and safe discontinuation of MV should be the objective for
the majority of patients. Many reasons may contribute to weaning, extubation failure and
prolongation of MV. Critical illness myopathy, induced by immobilisation and prolonged MV,
may represent a main factor and early rehabilitation may reverse these conditions and improve
the success of weaning from MV.The objective of this study is to evaluate the effect of an
early chair sitting (while the patient is awake but still mechanically ventilated) on weaning
from mechanical ventilation and ICU mortality.
Methods: Chronic respiratory failure patients with an acute decompensation and requiring MV
for more than 48 hours will be randomized to 2 groups at the initiation of weaning schedule:
the studied group (20 patients): chair-sitting group will be transferred from bed to arm
chair for at least 1 hour and once a day; the control group will stay in bed until
extubation. Ventilator free days, extubation failure, nosocomial infections, ICU mortality,
ICU length of stay are assessed and compared between groups. Expected results: Early chair
sitting would decrease MV duration, number of extubation failure, nosocomial infections and
ICU mortality. Feasibility and safety of this intervention will also be evaluated and also
the related work load.
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