Explore the Association Between the Emotion Recognition and the Attention Processing Under the Emotional Stimuli in ADHD

Attention Deficit/Hyperactivity Disorder Clinical Trial

Official title:

Explore the Association Between the Emotion Recognition and the Attention Processing Under the Emotional Stimuli in ADHD

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02017483
• Other study ID #: 201211008RIB
• Status: Recruiting
• Phase: N/A
• First received: December 4, 2013
• Last updated: December 16, 2013
• Start date: July 2013
• Est. completion date: January 2016

Study information

• Verified date: December 2013
• Source: National Taiwan University Hospital
• Contact: Susan Shur-Fen Gau, MD, PhD
• Phone: 886-2-23123456
• Email: gaushufe[@]ntu.edu.tw
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

Lots of studies suggest that children with ADHD have deficits in facial emotion recognition, especially for the negative emotion. But there were arguments for this deficit is a secondary problem due to the general attention impairment in ADHD, or a specific social cognitive processing to ADHD. The objectives of this study are to investigate that association between the deficits in facial emotion recognition and the emotional attention processing in ADHD. In this study, the investigators use the emotion attentional bias and emotional go / no go paradigm to answer this question.

Description:

The sample will consist of 100 children and adolescent with ADHD and 100 typical controls, ages 8-16. The ADHD group inclusion criteria are patients who have clinically diagnosis of DSM-IV ADHD confirmed by the K-SADS-E, and have IQ > 80; and whose parents consent to this study.

The measurements will be included:

1. Diagnostic assessment tools:

• Chinese version of Kiddie-Schedule for Affective Disorders and Schizophrenia-Epidemiology version.

• Conners' Parent/Teacher Rating Scale- Revised: Short Form, CPRS-R:S/CTRS-R:S.

• Swanson, Nolan, and Pelham, Version Ⅳ（SNAP-Ⅳ）Rating Scale - Parent/ Teacher Form.

2. Emotion assessment tools:

• Facial emotion recognition task.

• Emotional attentional bias task.

• Emotional Go/ No Go task.

3. Cognitive assessment tool:

• Wechsler Intelligence Scale for Children-Fourth Edition Chinese Version.

This study could offer the suggestion for the further intervention of social function in ADHD.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: January 2016
• Est. primary completion date: January 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 8 Years to 16 Years

Eligibility

Inclusion Criteria:

1. Control group

• The subjects without ADHD.

• Ages range from 8 to 16

• Full scale IQ = 80

• The subjects who and whose parents consent to this study.

2. ADHD group

• Patients who have clinically diagnosis of DSM-IV ADHD confirmed by the K-SADS-E.

• Ages range from 8 to 16

• Full scale IQ = 80

• Patients who and whose parents consent to this study.

Exclusion Criteria:

• Mental Retardation

• Schizophrenia, Schizoaffective Disorder

• Mood Disorders

• Organic Psychosis

• Learning Disorder

• Pervasive Developmental Disorder

• The subjects of control group if have a history of the following condition as defined by DSM-IV: ADHD in addition to the above exclusion criteria will be excluded.

Study Design

Observational Model: Case Control

Related Conditions & MeSH terms

• Attention Deficit Disorder with Hyperactivity
• Attention Deficit/Hyperactivity Disorder

Locations

Country	Name	City	State
Taiwan	National Taiwan Univeristy Hospital	Taipei

Sponsors (2)

Lead Sponsor	Collaborator
National Taiwan University Hospital	National Science Council, Taiwan

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	The attentional inhibition control(omission errors and commission errors) in emotional go/no go task	Investigator used go/ no go task to assess participants' omission errors and commission errors, participants just need to press the keyboard and the number of errors were recorded.	up to 2 years	Yes
Primary	The error rate in facial emotion judgements on computerized task	Investigator used the e-prime program to assess the error rate in facial emotion judgements. Participants need to judge the emotion of the face stimuli presented on the laptop.	up to 2 years	Yes
Secondary	The reaction time of attentional bias for pairs of face stimuli(happy/neutral or angry/neutral faces) on dot-prob task	Investigator presented pairs of face stimuli with emotional and neutral expressions and probed the allocation of attention to these stimuli for presentation times of 150 and 500 ms to assess the reaction time of attentional bias. Participants need to press the dot after the prob.	up to 2 years	Yes