Neonatal Respiratory Distress Syndrome Clinical Trial
— twinsOfficial title:
Nasal Intermittent Positive-Pressure Ventilation vs Nasal Continuous Positive Airway Pressure for Twin Infants With Respiratory Distress Syndrome
In the present study, we hypothesized that primary mode nIPPV initiated shortly after birth would decrease the incidence of intubation or death in twin infants when compared to nCPAP.
Status | Completed |
Enrollment | 286 |
Est. completion date | July 30, 2017 |
Est. primary completion date | July 30, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A to 6 Hours |
Eligibility |
Inclusion Criteria: - Twins - Clinical diagnosis of mild-moderate respiratory distress syndrome - requiring a fraction of inspired oxigen (FiO2 ) <0.40 to keep oxygen saturation of 90%-95% - a chest X-ray suggestive of early stage hyaline membrane disease, (i.e. mild microgranulia and air bronchogram) Exclusion Criteria: - pneumothorax - pneumomediastinum - surgical diseases - cardiac diseases - intraventricular hemorrage - major congenital defects |
Country | Name | City | State |
---|---|---|---|
China | Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University | Chongqing | Chongqing |
Lead Sponsor | Collaborator |
---|---|
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | death | 3 months | ||
Primary | incidence of intubation | 48h | ||
Secondary | incidence of BPD | 1 month |
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