Left Ventricular Diastolic Dysfunction Clinical Trial
Official title:
Effect of Linagliptin Therapy on Myocardial Diastolic Function in Patients With Type 2 Diabetes Mellitus
Examination of the effect of Linagliptin versus placebo on diastolic function in patients
with type 2 diabetes mellitus and diastolic dysfunction as assessed by transthoracic
echocardiography.
Furthermore the effect on serum levels of NT-pro BNP as a biomarker of heart failure will be
investigated.
Treatment:
The Patients will receive Linagliptin 5 mg QD or placebo for a period of 6 months.
The echocardiography and 24h RR measurement will be performed at baseline and 6 months after
initiation of the therapy.
The blood chemistry (Glucose, HbA1c, BNP) will be evaluated at baseline as well as 3 and 6
months after initiation of the therapy.
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