MRI for the Early Evaluation of Acute Intracerebral Hemorrhage

Brain Neoplasms Clinical Trial

Official title: MRI for Early Identification of Underlying Pathology in Patients With Acute Intracerebral Hemorrhage

Status Completed

Clinical Trial Summary

What happens in the borderzone of a cerebral hemorrhage remains widely onknown and furhter the best timing for doing MR to look for vascular pathology in cerebral hemorrhage has not yet been determined. In this study we do acute MRS, a non-invasive imaging mathod to detemine the biochemsty in the border zone and structural MRI for vascular malformation. We repeat structural MRI after 8 weeks.

Clinical Trial Description

In this study we want to investigate the ability of MRI to identify underlying pathology (tumor or vascular malformations) in acute patients admitted with intracerebral hemorrhage (ICH). Today MRI-scan is normally done 3-4 weeks after symptom onset but very little is known about the early use of MRI to detect underlying pathology. This would allow an early intervension and less uncertainty for the patients.

We further want to investigate the metabolic penumbra-zone surrounding the hematoma. It is the current perception in the litterature that this zone represent a metabolic zone marked by apoptosis and inflammation rather than ischemia.

We are planning to:

When patients arrive in our stroke department they will within 7 hours be subject to MRI scan with the protocoled sequences. Standard sequences: Axial T2, axial DWI, Sagittal T1, T2 flair og axial GRE-sequence.

Susceptibility weighted imaging (SWI)

Chemical Shift Imaging (CSI) multivoxel spectroscopi

Post contrast 3D box reconstruction

After 8 weeks the patients are subject to another MRI-Scan in accordance with the standard clinical guideline to rule out underlying pathology.

After 3 month the patients are seen in the outpatient-clinic to follow-up evaluation.

To sum up the purpose of this present study is to conduct a pilot investigation of MRI in the early evaluation of ICH-patients. Second it is our intension to use multivoxel magnetic resonance spectroscopy to study the metabolic penumbra-zone surrounding the ICH. ;

Related Conditions & MeSH terms

• Arteriovenous Malformations
• Brain Neoplasms
• Cerebral Hemorrhage
• Hemorrhage
• Intracranial Arteriovenous Malformations
• Intracranial Hemorrhage, Hypertensive
• Intracranial Hemorrhages

• NCT number: NCT01689402
• Study type: Observational
• Source: Bispebjerg Hospital
• Status: Completed
• Start date: April 2012
• Completion date: May 2017