Schizophrenia Clinical Trial
Official title:
Mediators and Moderators of Treatment Outcome in Recent-Onset Psychosis
Multifamily group psychoeducation [MFG] and group cognitive behavioral therapy [GCBT] are evidence-based treatments for first episode psychosis. However, like all treatments for psychotic disorders, neither MFG nor GCBT are perfect—some individuals who receive these interventions still experience a worsening of psychotic symptoms. Clarifying the mechanisms through which these interventions produce their clinical benefits and identifying the factors that may maximize an individual's response to MFG and GCBT could improve the clinical benefits facilitated by these two interventions.
Background
There is growing evidence that the majority of the psychosocial deterioration that
accompanies psychotic disorders occurs during the first few years of illness and that the
prevention or delay of early deterioration may be associated with a better course of illness.
Two interventions which have been shown to improve the course of recent-onset psychosis are
multifamily group psychoeducation [MFG] and group cognitive behavioral therapy [GCBT]. Both
family psychoeducation and cognitive behavioral therapy have been recommended as components
of usual care for psychotic disorders by the Schizophrenia Patient Oriented Research Team
convened by the U.S. Department of Health and Human Services (10) as well as other
international health organizations. However, like all treatments for psychotic disorders,
neither MFG nor GCBT are perfect—some individuals who receive these interventions still
experience a worsening of psychotic symptoms. Clarifying the mechanisms through which these
interventions produce their clinical benefits and identifying the factors that may maximize
an individual's response to MFG and GCBT could improve the clinical benefits facilitated by
these two interventions.
Purpose and Objectives
The goal of this study is to clarify the mechanisms through which MFG and GCBT produce their
clinical benefits (i.e., mediators) and identify the factors that may maximize an
individual's response to these two empirically-validated interventions (i.e., moderators).
Methods
All participants will be provided with 2 years of of GCBT and MFG and will complete regular
assessments with regard to clinical and functional outcomes as well as potential mediators
and moderators of these outcomes.
Significance of the Study
Clarifying the mechanisms through which these interventions produce their clinical benefits
and identifying the factors that may maximize an individual's response to MFG and GCBT could
lead to improvements in the treatment of first-episode psychosis.
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