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NCT01500954 Clinical Trial

Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma

Cutaneous Squamous Cell Carcinoma Clinical Trial

Official title:
Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01500954
Other study ID # microRNA7
Secondary ID
Status Completed
Phase N/A
First received December 23, 2011
Last updated October 15, 2012
Start date October 2011
Est. completion date December 2011

Study information
Verified date October 2012
Source Ruhr University of Bochum
Contact n/a
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Observational

Clinical Trial Summary

MicroRNAs (miRNAs) are a novel class of short RNAs which have shown to be dysregulated in a variety of cancers. Data of miRNA expression in cutaneous squamous cell carcinoma (cSCC) is very limited and microarray based genome wide miRNA expression profiles of cSCC have not been investigated so far.

Description:

Patients with cutaneous SCC were enrolled in the present study. Tumor biopsies were taken from the center of the tumor. Adjacent healthy skin was biopsied as a control (intraindividual control). miRNA expression profiles of specimen were detected by microarray miRNA expression profiling. Microarray results were confirmed by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).

Recruitment information / eligibility
Status Completed
Enrollment 7
Est. completion date December 2011
Est. primary completion date December 2011
Accepts healthy volunteers No
Gender Both
Age group 1 Year and older
Eligibility Inclusion Criteria:

- cutaneous squamous cell carcinoma

Exclusion Criteria:

- other skin cancer than cutaneous squamous cell carcinoma

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Germany Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum Bochum NRW

Sponsors (1)
Lead Sponsor Collaborator
Ruhr University of Bochum

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Sand M, Skrygan M, Georgas D, Sand D, Hahn SA, Gambichler T, Altmeyer P, Bechara FG. Microarray analysis of microRNA expression in cutaneous squamous cell carcinoma. J Dermatol Sci. 2012 Dec;68(3):119-26. doi: 10.1016/j.jdermsci.2012.09.004. Epub 2012 Sep — View Citation

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