Ovarian Hyperstimulation Syndrome Clinical Trial
Official title:
Does Intravenous Calcium Infusion Effectively Prevent OHSS : a Randomised Controlled Trial
There are many protocols for prevention of ovarian hyperstimulation syndrome, intravenous calcium is a novel protocol. But still there is lack of evidence of it is real effect in prevention of OHSS & the mechanism of its action is still questionable . In the study the investigators try to search for the evidence for its effect & the real mechanism for its action.
The study population will be divided into 2groups each containing 100 infertile couples
candidate for ICSI.
Group (A)active group: administration of 10% Intravenous calcium gluconate 10 ml in 200 mL
of physiologic saline on the day of ovum pickup, day 1,day 2, and day 3 after ovum pickup.
Intravenous infusion was performed within 30 minutes.
Group (B): placebo group: administration of 200 mL of 0.9% saline on the day of ovum pickup,
day 1,day 2, and day 3 after ovum pickup. Intravenous infusion was performed within 30
minutes
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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