Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy

Acute Respiratory Distress Syndrome Clinical Trial

Official title:

Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy Under Volume Controlled (VC) and Pressure Controlled (PC) Ventilation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01078831
• Other study ID #: REK-HO Ref 191-01055, 03052001
• Status: Completed
• Phase: N/A
• First received: March 1, 2010
• Last updated: November 10, 2010
• Start date: March 2002
• Est. completion date: April 2010

Study information

• Verified date: November 2010
• Source: Oslo University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway: Ethics Committee
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.

Description:

Mechanically ventilated patients often need bronchoscopy as a diagnostic procedure or for visually directed elimination of secretions. Partial endotracheal tube occlusion by the bronchoscope increases airflow resistance. Inhibition of inspiratory flow may be compensated for by augmented inspiratory pressure. Reduced expiratory flow however, cannot be compensated for by most ventilators and could lead to higher airway - and intrathoracic pressures that are not detected by pressure transducers in the ventilator tubing. In this study we compare changes in ventilation, airway pressures, ventilator pressures and blood gases during bronchoscopy of intubated patients in both volume controlled and pressure controlled ventilation. Our hypothesis are that 1) increased resistance in the tube during bronchoscopy leads to high intrabronchial airway pressures when the ventilator is in volume controlled mode, and 2) when the ventilator is in pressure controlled mode, increased resistance in the tube during bronchoscopy leads to reduced Tidal Volume and moderately increased paCO2.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: April 2010
• Est. primary completion date: April 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• ARDS/ALI patients on mechanical ventilation

• endotracheal tube size 7-9mm

• age > 18 years

• therapeutic or diagnostic bronchoscopy requested by staff physician

Exclusion Criteria:

• SpO2 < 90%

• unstable BP

• pneumothorax

• acute cardiovascular disease

• cerebrovascular or other condition that requires stable BP and saturation

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acute Lung Injury
• Acute Lung Injury (ALI)
• Acute Respiratory Distress Syndrome
• Lung Injury
• Respiratory Distress Syndrome, Adult
• Respiratory Distress Syndrome, Newborn

Intervention

Other:
• Bronchoscopy
Airway pressures, ventilation changes and blood gas changes are recorded in a group of intubated patients on mechanical ventilation before and after bronchoscope insertion. The registration is done immediately before a therapeutic/diagnostic bronchoscopy requested by a staff physician not involved n the study.

Locations

Country	Name	City	State
Norway	Oslo University Hospital - Ulleval	Oslo

Sponsors (1)

Lead Sponsor	Collaborator
Oslo University Hospital

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in ventilation, airway pressures and blood gases after bronchoscope insertion.	paO2, paCO2 (kPa), airway and ventilator pressures (cmH2O)	2 minutes after bronchoscope insertion/ mode change	Yes