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Study of Histological Samples From Patients With Hereditary Haemorrhagic Telangiectasia

Telangiectasia, Hereditary Hemorrhagic Clinical Trial

Official title:
Histological Samples From Patients With Hereditary Haemorrhagic Telangiectasia

Clinical Trial Summary

In this study the investigators will obtain histological samples from people with hereditary haemorrhagic telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome).

Clinical Trial Description

HHT is an inherited condition that leads to the development of dilated and fragile blood vessels. We propose to obtain small skin samples from patients with HHT in order to analyze the samples using histological methods, and study the properties of vascular endothelial cells derived from patients. We hypothesize that these cells will show differences when compared to normal endothelial cells, which may be confirmed in single time point analyses in histological samples. We anticipate that that these findings may help to explain aspects of the HHT disease phenotype. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00733655
Study type Observational
Source Imperial College London
Contact
Status Completed
Phase
Start date September 2008
Completion date August 2016
View Details
See also
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Completed NCT01408030 - North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Phase 2
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