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Study of Endothelial Cells in Patients With Hereditary Haemorrhagic Telangiectasia

Telangiectasia, Hereditary Hemorrhagic Clinical Trial

Official title:
In Vitro Studies pf Endothelial Cells Derived From HHT Patients

Clinical Trial Summary

Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels. We propose to culture endothelial cells from patients with HHT, to culture cells that express the proteins mutated in HHT, namely endoglin and ALK-1. We will study the properties of these cells which will involve their growth in different conditions and anticipate that DNA, mRNA and proteins will be extracted from these cells for study of cell responses and association with expression levels of endoglin and ALK-1. We hypothesize that these cells which express "half-normal" endoglin or ALK-1 will show altered protein synthetic differences when compared to normal white blood cells. We anticipate that that these findings may help to explain aspects of the HHT disease phenotype.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00733629
Study type Observational
Source Imperial College London
Contact
Status Withdrawn
Phase
Start date August 2002
Completion date March 2006
View Details
See also
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