Bronchiolitis Obliterans Syndrome Clinical Trial
Official title:
Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation. Can We Help Diagnose Acute Rejection and Better Predict Bronchiolitis Obliterans?
A major source of graft failure and dysfunction in lung transplantation is known to be
bronchiolitis obliterans (BO)and its clinical correlate called bronchiolitis obliterans
syndrome(BOS). In fact, BOS is the leading cause of death in lung recipients beyond one year
post transplant. Currently, our ability to assess lung injury after transplant is less than
ideal.
The purpose of this study is to use new computerized tomography(CT) technology, specifically
, 64 bit acquisition, to detect and predict the onset of lung injuries, with the hope of
finding better therapies that currently exist.
Total enrollment : 10
Lung transplant patients will undergo CT Scans before scheduled bronchoscopies which are
routinely performed at 1, 3, 6, 9, and 12 months post transplant. Imaging will be done with
the newest generation scanner, with intent to analyze all pertinent areas of the lung for
pathology, but especially the bronchial anastomoses, the lung parenchyma with focus on gas
exchanging lobules of the lung, and any suspected abnormalities from physical exam,
laboratory tests, or prior chest xray.
CT imaging will precede bronchoscopy and biopsy so that CT interpretation will be
unencumbered by changes due to the bronchoscopic procedure.
;
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01807975 -
Forced Oscillation Versus Spirometry in Diagnosing Post Pulmonary Transplant Bronchiolitis Obliterans Syndrome
|
N/A | |
| Completed |
NCT01009619 -
Azithromycin in Bronchiolitis Obliterans Syndrome
|
Phase 4 | |
| Recruiting |
NCT04391335 -
Novel Pulmonary Function Measures for Diagnosis of Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem-Cell Transplantation in Children
|
||
| Recruiting |
NCT05250037 -
The Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Cell Transplantation (The RV-BOS Study)
|
||
| Enrolling by invitation |
NCT04039347 -
Extension Trial on Efficacy / Safety of L-CsA + SoC in Treating BOS in Post Single or Double Lung Transplant (BOSTON-3)
|
Phase 3 | |
| Recruiting |
NCT05413356 -
Ruxolitinib for Newly Diagnosed Bronchiolitis Obliterans Syndrome
|
Phase 2 | |
| Recruiting |
NCT00774449 -
Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation
|
N/A | |
| Recruiting |
NCT05922761 -
BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)
|
Phase 2 | |
| Terminated |
NCT03978637 -
Safety and Efficacy of Itacitinib in Participants With Bronchiolitis Obliterans Syndrome Following Lung Transplantation
|
Phase 1/Phase 2 | |
| Completed |
NCT02316392 -
Imaging and Understanding BOS in Lung Transplantation
|
||
| Recruiting |
NCT06018766 -
LAM-001 in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome.
|
Phase 2 | |
| Recruiting |
NCT02669251 -
Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation
|
Phase 1/Phase 2 | |
| Completed |
NCT02863835 -
Evaluation of Electrical Impedance Tomography for the Diagnosis of Chronic Rejection in Lung Transplants Recipients
|
N/A | |
| Recruiting |
NCT03072849 -
Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation
|
N/A |