One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

Thoracic Surgery With One-lung Ventilation Clinical Trial

Official title:

Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00515905
• Other study ID #: StV 20-2004
• Status: Completed
• Phase: N/A
• First received: August 13, 2007
• Last updated: September 14, 2010
• Start date: October 2004
• Est. completion date: September 2007

Study information

• Verified date: March 2008
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Swissmedic
• Study type: Interventional

Clinical Trial Summary

One-lung ventilation; organ protection; volatile anesthetics

One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:

1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse?

2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.

• Trial with immunomodulatory product / biological

Recruitment information / eligibility

• Status: Completed
• Enrollment: 76
• Est. completion date: September 2007
• Est. primary completion date: September 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion criteria:

• Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation

Exclusion criteria:

• Immunosuppressive therapy

• Ongoing inflammatory processes

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Thoracic Surgery With One-lung Ventilation

Intervention

Drug:
• Sevoflurane/propofol
Sevoflurane/propofol

Locations

Country	Name	City	State
Switzerland	University Hospital of Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	One-lung ventilation measurement in the re-ventilated lung after short-period pulmonary collapse		Sep 07	No