Thoracic Surgery With One-lung Ventilation Clinical Trial
Official title:
Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery
One-lung ventilation; organ protection; volatile anesthetics
One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis
will be tested in this study:
1. Are inflammatory mediators increased in the re-ventilated lung after short-period
pulmonary collapse?
2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated
lung? Therefore, this study will elucidate the potential protective effect of a
volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the
respiratory compartment of the lung, i.e. the alveolar epithelium.
- Trial with immunomodulatory product / biological
n/a
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention