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A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients

Respiratory Distress Syndrome, Adult Clinical Trial

Clinical Trial Summary

30% of ARDS patients ventilated according to NIH protocol presents CT scan evidence of hyperinflation. Functional analysis of pressure-time curve (Stress Index=SI) has been shown to identify this condition in experimental settings. We tested the hypothesis that the SI is an accurate predictor of mechanical stress due to overdistention in ARDS patients.

Clinical Trial Description

The study presents two parts : a preliminary validation study and a clinical study. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

  • Acute Lung Injury
  • Respiratory Distress Syndrome, Adult
  • Respiratory Distress Syndrome, Newborn
Clinical Trial Details
NCT number NCT00465374
Study type Interventional
Source University of Turin, Italy
Contact V. M. Ranieri, MD
Phone 00390116334001
Email marco.ranieri@unito.it
Status Recruiting
Phase Phase 3
Start date October 2002
View Details
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