COVID-19 Vaccination in Rheumatic Disease Patients

Status Terminated

Clinical Trial Summary

The research is being done to study the immune responses to COVID-19 vaccination in patients with rheumatic diseases.

Clinical Trial Description

Because patients treated with immunosuppressive agents have been excluded from initial clinical trials, and most patients with rheumatic diseases are taking immunosuppressants, the immune responses towards the mRNA COVID19 vaccines in these patients remains unknown. The goal is to study the immune response to COVID-19 vaccination in patients with rheumatic diseases. Blood samples collected before and longitudinally after mRNA-based COVID-19 vaccination (i.e., Pfizer and Moderna vaccines) will enable detailed immunological investigation of the interaction between COVID-19 vaccination and rheumatic diseases. These efforts will provide novel insights into the COVID-19 vaccine response in patients with rheumatic diseases, and eventually would inform clinical management to improve patient care. ;

Study Design

Related Conditions & MeSH terms

Ankylosing Spondylitis
Arthritis
Arthritis of Multiple Sites Associated With Inflammatory Bowel Disease (Diagnosis)
Arthritis, Psoriatic
Collagen Diseases
Gout
Inflammatory Bowel Diseases
Inflammatory Myositis
Lupus Erythematosus, Systemic
Myositis
Osteoarthritis
Psoriatic Arthritis
Rheumatic Diseases
Sjogren's Syndrome
Spondylitis
Spondylitis, Ankylosing
Systemic Lupus Erythematosus

Clinical Trial Details

NCT number	NCT04839315
Study type	Interventional
Source	Mayo Clinic
Contact
Status	Terminated
Phase	Early Phase 1
Start date	February 15, 2021
Completion date	February 9, 2022

View Details

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