Clinical Trials Logo

Osteoarthritis clinical trials

View clinical trials related to Osteoarthritis.

Filter by:

NCT ID: NCT00588783 Terminated - Clinical trials for Rheumatoid Arthritis

I-beam and Cruciate Tibial Components Used in Total Knee Replacement

Start date: August 2006
Phase: N/A
Study type: Observational

The purpose of this study is to compare the clinical outcomes of using an I-beam or cruciate tibial component in total knee replacement.

NCT ID: NCT00579059 Terminated - Clinical trials for Rheumatoid Arthritis

Maxim® Knee Pop-Top® Tibia vs. Regular Maxim® Knee Tibia

Start date: May 2004
Phase: N/A
Study type: Interventional

The purpose of this prospective clinical data collection is to compare the outcomes of two different tibial bearings: the Maxim® Pop-Top® Tibia and Maxim® Modular Tibia.

NCT ID: NCT00546598 Terminated - Osteoarthritis Clinical Trials

Post-approval Study of the DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System

Start date: January 1, 2006
Phase: Phase 4
Study type: Interventional

This study is being conducted to gather medium and long-term information regarding the performance and safety of the commercially available DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System.

NCT ID: NCT00543465 Terminated - Osteoarthritis Clinical Trials

12-Week No-Rofecoxib Plus Aspirin Endoscopy Study (0782-003)

Start date: August 2004
Phase: Phase 2
Study type: Interventional

This study will look at the incidence of gastric and/or duodenal ulcers in patients with osteoarthritis or rheumatoid arthritis in four different treatment groups (a) MK0782 21 mg plus enteric-coated aspirin, (b) MK0782 42 mg plus enteric-coated aspirin, (c) celecoxib 200 mg plus enteric-coated aspirin, and enteric-coated aspiring alone. This is an early phase trial and some specific protocol information is in progress and not publicly available at this time. (Full information is available to trial participants).

NCT ID: NCT00532038 Terminated - Osteoarthritis Clinical Trials

A Phase 3 Study to Evaluate the Long-Term Safety of ThermoProfen™ in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee.

Start date: September 2007
Phase: Phase 3
Study type: Interventional

ThermoProfen is a transdermal ketoprofen patch that is integrated with a long-lasting CHADD (Controlled Heat-Assisted Drug Delivery) unit for the treatment of chronic pain associated with osteoarthritis. This study will evaluate the safety of long-term administration of ThermoProfen™ for the pain associated with osteoarthritis of the knee in adults. The study will be conducted in patients with pain associated with osteoarthritis and who have completed a previous efficacy study of ThermoProfen.

NCT ID: NCT00522080 Terminated - Clinical trials for Hip and Knee Osteoarthritis

Screening for Hip and Knee Osteoarthritis in the General Population: Predictive Value of a Questionnaire and Prevalence Estimates

Start date: March 2005
Phase: N/A
Study type: Observational

Objective: To study the feasibility and validity of a two-step telephone screening procedure for symptomatic knee and hip osteoarthritis (OA) in the general population. Method: The screening questionnaire was based on signs and symptoms, previous diagnosis of OA, and validated OA criteria. A random sample of telephone numbers was obtained and, at each number, one individual aged 40 to 75 years was included. A physical examination and knee or hip radiographs were offered when the screen was positive. A sample of individuals with negative screens was also examined. The diagnosis of hip/knee OA was based on either American College of Rheumatology criteria for signs and symptoms and Kellgren-Lawrence radiographic stage 2 or greater. Prevalence rates were estimated with correction for the performance of the screening procedure.

NCT ID: NCT00521989 Terminated - Knee Osteoarthritis Clinical Trials

CRx-102 Osteoarthritis Multicenter Evaluation Trial

COMET-1
Start date: August 2007
Phase: Phase 2
Study type: Interventional

CRx-102 is a synergistic combination drug candidate containing the cardiovascular drug dipyridamole and a very low dose of the glucocorticoid prednisolone. CRx-102 is believed to work through a novel mechanism of action in which dipyridamole selectively amplifies the anti-inflammatory and immunomodulatory activities of the glucocorticoid without replicating the dose-dependent adverse effects. CRx-102 has been associated with clinical benefit in proof of concept studies in subjects with hand OA and RA. This is the first study to explore the efficacy of CRx-102 in knee OA. It is considered a dose-finding study and will also compare the potential benefits of CRx-102 treatment to both prednisolone administered alone and to placebo in this indication.

NCT ID: NCT00492219 Terminated - Osteoarthritis Clinical Trials

Postoperative Function Following Partial and Total Knee Replacement

Start date: October 2006
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if patients with a fixed-bearing or mobile-bearing partial knee replacement perform functional activities differently than patients that have had total knee replacement or healthy volunteers that have not had knee surgery. The activities we are interested in include getting up out of a chair, stepping up and over a small wooden box, and standing still with the knees straight and also bent to 45 degrees.

NCT ID: NCT00485472 Terminated - Osteoarthritis Clinical Trials

Trial to Assess Efficacy and Safety of Lacosamide in Subjects With Osteoarthritis of the Knee

Start date: March 2007
Phase: Phase 2
Study type: Interventional

The purpose of this trial is to evaluate the effectiveness, safety and tolerability of lacosamide (LCM) 400mg/day in treating the signs and symptoms of osteoarthritis of the knee.

NCT ID: NCT00484718 Terminated - Osteoarthritis Clinical Trials

Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.

Start date: January 17, 2008
Phase: Phase 4
Study type: Interventional

The Purpose of this trial is to evaluate the use of a cross-over trial design in an osteoarthritis population. We will determine the inter- and intra-subject variability in osteoarthritis (OA) endpoints and evaluate if efficacy can be detected by measuring OA endpoints following treatment with 2 different types of analgesics in a crossover study of this design.