Osteoarthritis Knee Clinical Trial
Official title:
Intra-articular Platelet Rich Plasma vs Corticosteroid in Treatment of Knee Osteoarthritis
Knee osteoarthritis is the most common type of osteoarthritis in the lower extremity and constitutes 23% of all arthritis cases, about 13% of females and 10% of males aged above 60 years have symptomatic knee OA. Intra-articular corticosteroids (IACs) are a frequently-used treatment regimen for pain relief from symptomatic knee OA as it inhibits inflammation and reduces prostaglandin synthesis. Platelet-rich plasma (PRP) is an autologous blood product containing a high percentage of various growth factors (GFs), such as fibroblast growth factor, epidermal growth factor, vascular endothelial growth factor, transforming growth factor-β and platelet-derived growth factor. The aim of this study is to compare effect of intra-articular injection of platelet rich plasma versus corticosteroid in treatment of primary knee osteoarthritis.
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | December 2023 |
Est. primary completion date | October 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 70 Years |
Eligibility | Inclusion Criteria: - Patients 40-70 years of age suffering from knee OA with Kellgren Lawrence grade II or III on standing antero-posterior and lateral knee radiographs. - Patients diagnosed according to ACR classification criteria. Exclusion Criteria: - Systemic diseases as Patients having diabetes mellitus,Cardiovascular diseases or coagulopathies. - Those receiving treatment with anticoagulant , anti_platelet medications or systemic corticosteroid 10 days before injection or recent use of NSAIDs. - Pregnant and breast feeding females. - Patients have hemoglobin values <10 g/dl or platelet values<150,000/ml. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Benha University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assessment of knee pain, stiffness and physical function prior knee injection | Assessment through the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. The final score for the WOMAC was determined by adding the aggregate scores for pain, stiffness, and function. Scores range from 0 to 96 for the total WOMAC where 0 represents the best health status and 96 the worst possible status. | Assessment will be done just before injection | |
Primary | Assessment of knee pain, stiffness and physical function 2 weeks after injection | Assessment through WOMAC score | 2 weeks after injection | |
Primary | Assessment of knee pain, stiffness and physical function 6 weeks after injection | Assessment through WOMAC score | 6 weeks after injection | |
Primary | Assessment of knee pain, stiffness and physical function 12 weeks after injection | Assessment through WOMAC score | 12 weeks after injection |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT06232018 -
A Comparison of 2-octyl Cyanoacrylate Skin Adhesive and Polyester Mesh for Wound Closure in Total Knee Arthroplasty, A Randomized Controlled Study
|
N/A | |
Recruiting |
NCT02200107 -
Integrated Treatment Program for Osteoarthritis of the Knee
|
N/A | |
Recruiting |
NCT05783154 -
Effect of Mesenchymal Stem Cells in Primary Knee Osteoarthritis
|
Phase 2/Phase 3 | |
Completed |
NCT02833545 -
Safety and Efficacy of Intra-articular Ozone Injections for Knee Osteoarthritis
|
Phase 4 | |
Recruiting |
NCT01569230 -
Efficacy and Safety Study of Individualized and Standardized Acupuncture Treatment for Knee Osteoarthritis
|
N/A | |
Completed |
NCT02314715 -
Neuromuscular Control in Knee Osteoarthritis
|
N/A | |
Active, not recruiting |
NCT03548792 -
Comparison of an Old Versus a New Total Knee Replacement
|
N/A | |
Completed |
NCT02285725 -
Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid
|
N/A | |
Completed |
NCT02544802 -
Mesenchymal Stem Cell Treatment for Primary Osteoarthritis Knee
|
Phase 1 | |
Completed |
NCT02919020 -
Efficacy of Proprioceptive Neuromuscular Facilitation in Older Women With Gonarthrosis
|
N/A | |
Completed |
NCT02050438 -
How Total Knee Prosthesis Dessigns Influence in Quality of Live
|
N/A | |
Completed |
NCT01492660 -
Echogenic Versus Stimulating Needle and Catheter for Sciatic Blocks
|
Phase 3 | |
Completed |
NCT01934218 -
Gel-One Treatment in Knee Osteoarthritis
|
N/A | |
Completed |
NCT04324931 -
Effect of Biomechanical Correction in Medial Tibiofemoral Joint Osteoarthritis
|
N/A |