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NCT05617573 Clinical Trial

Synovitis in Patients With Osteoarthritis

Osteoarthritis, Knee Clinical Trial

Official title:
Correlations Between Microscopic Features of Synovium and Clinical Parameters in Patients With Advanced Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05617573
Other study ID # OASynoviumAHQD
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 1, 2020
Est. completion date December 31, 2022

Study information
Verified date January 2023
Source The Affiliated Hospital of Qingdao University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.

Recruitment information / eligibility
Status Completed
Enrollment 272
Est. completion date December 31, 2022
Est. primary completion date December 31, 2022
Accepts healthy volunteers No
Gender All
Age group 55 Years to 75 Years
Eligibility Inclusion Criteria: - patients undergoing elective, unilateral, primary TKA for advanced osteoarthritis. Exclusion Criteria: - revisions, bilateral procedures, alcohol or medical abuse, administration of any glucocorticoids during the 3 months prior to surgery, and/or a history of serious cardiac or cerebrovascular problems, severe liver or kidney failure, and/or connective tissue disease including rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus.

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Total knee arthroplasty due to advanced osteoarthritis.
Postoperative usage of intravenous methylprednisolone

Locations
Country Name City State
China The affiliated hospital of Qingdao University Qingdao Shandong

Sponsors (1)
Lead Sponsor Collaborator
The Affiliated Hospital of Qingdao University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Correlation between pathological features and clinical scores 1 day.
Primary Correlation between pathological features and laboratory index 1 day
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