Comparison Among the Effects of Blood Flow Restriction Training and Conventional Exercise in Knee Osteoarthritis.

Osteoarthritis, Knee Clinical Trial

Official title:

Effects of Blood Flow Restriction Training vs Traditional Exercise in Patients With Knee Osteoarthritis.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05058794
• Other study ID #: REC/00947 Farah Anwar
• Status: Completed
• Phase: N/A
• Start date: October 10, 2021
• Est. completion date: February 11, 2022

Study information

• Verified date: March 2022
• Source: Riphah International University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main objective of the study is to compare the effects of Blood flow Restriction training vs. traditional exercises on knee pain , knee functional disability and on quadriceps strength in patient with knee osteoarthritis.

Description:

Osteoarthritis is a degenerative disease affecting the most commonly weight bearing joint.The common form of arthritis is osteoarthritis (OA) causing structural changes in the joint. Age is a common factor affecting the strength and muscle mass.Worldwide there is a drastic increase of osteoarthritis in the older population. In the past 20 years the prevalence of knee pain increased and reached up to 50% in the older population. The most common OA affecting lower extremity is in the knee Joint.Majority of the people affected by knee OA are the older population. Knee Joints being the most weight bearing joint affected in OA causing pain , limiting function and mobility.Mobility and function may be affected in osteoarthritic population usually experience pain and stiffness. The main objective of this study is to compare the Effects of blood Flow restriction training vs conventional treatment exercises on knee pain, functional disability and quadriceps strengthening. The main purpose of this study is to improve the muscular strength of lower limbs which are being affected in a disease osteoarthritis in the adult population.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 42
• Est. completion date: February 11, 2022
• Est. primary completion date: February 11, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 60 Years

Eligibility

Inclusion Criteria:

• Pain : Subjects having unilateral or bilateral pain
• Pain type : subjects having chronic pain
• Includes diagnosed cases of knee osteoarthritis
• grades 2-3 according to the Kellgren and Lawrence method of grading
• Includes knee osteoarthritis patients with lateral tracking of patella which will assessed through Q angle test

Exclusion Criteria:

• Any other orthopaedic or neurological condition of hip and knee
• Sign and symptoms of lower motor neuron disease
• Current use of medication
• Radiculopathy
• Fracture
• Malignancy
• Thromboembolism
• Decreased range of motion

Related Conditions & MeSH terms

• Hypertrophy
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Other:
• Blood flow Restriction/Resistance Training
During each exercise, only blood flow in the involved leg was restricted using an aneroid sphygmomanometer. Prior to exercise the cuff was placed on the most proximal portion of the limb and limb occlusion pressure (LOP) was calculated in the body position that the Blood flow Restriction (BFR) stimulus would be applied. Blood Flow Restriction BFR pressure was set at 50% occlusion. Resistance applied for 1 minute (60 sec) with 30 % load of 1 repetition maximum. Subjects will receive treatment bilaterally. Participants will perform exercises 2 sets with 15 repetitions through 0 to 90 degrees.
• Conventional Therapy Group
Resistance applied for 1 minute (60 sec) with 30 % load of 1 repetition maximum. Subjects will receive treatment bilaterally.participants will perform 2 sets with 15 repetitions in (0 to 90 degree.)

Locations

Country	Name	City	State
Pakistan	Gulberg Medical Complex	Islamabad	Federal
Pakistan	Medcity International Hospital	Islamabad	Federal

Sponsors (1)

Lead Sponsor	Collaborator
Riphah International University

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle strength	Measurement of Quadriceps strength with portable weight machine.	6 weeks
Primary	Thigh Girth	Participants will be supine lying and knee in extension, standing or knee at 90 degree. Proximal to the patellar pole superiorly one measurement with a non-elastic tape at the inguinal fold, then mark the mid-point at the mid-thigh level measuring in centimeters/inches.	6 weeks
Primary	Numeric Pain Rating Scale ( NPRS)	Patient will be asked if there is any pain in knee from the scale of 0 to 10.	6 weeks
Primary	Q angle Measurement	Subject will be in supine position with knee extension and quadriceps are relaxed, examiner will measure the q angle with flexible inch tape and goniometer. The Q- angle is measured by extending a line through the center of the patella to the anterior superior iliac spine and another line from the tibial tubercle through the center of the patella.	6 weeks