Clinical Trials Logo

Clinical Trial Summary

This is a randomized, single-blind, parallel, active-controlled study to evaluate the efficacy and safety of bone marrow mesenchymal stem cells (BM-MSCs), Chondrochymal®, in subjects aged 40 to 80 with knee OA.


Clinical Trial Description

This phase IIb study is a prospective, single-blind, parallel, active-controlled study to evaluate the efficacy and safety of Chondrochymal® in subjects with knee OA. All the subjects will be enrolled in Taiwan. The target population is composed of subjects with unilateral or bilateral OA knee(s). For subjects with bilateral OA knees, only the knee with more severe symptoms will be selected as the target knee. If the severities of the OA symptoms are the same for both knees, the knee with more pain should be selected, where the WOMAC pain score will take the priority over the VAS index. Eligible subjects will be randomized into one of the study groups, Chondrochymal® Group or Control Group, in 1:1 ratio. To keep the blindness, the subject's eyesight will be masked by a curtain while receiving the IA injection. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05027581
Study type Interventional
Source Taiwan Bio Therapeutics Co., Ltd.
Contact chun-yao yang, PhD
Phone +886 226956382
Email [email protected]
Status Not yet recruiting
Phase Phase 2
Start date September 10, 2021
Completion date September 10, 2024

See also
  Status Clinical Trial Phase
Recruiting NCT03895489 - Effectiveness of the Journey Total Knee Arthroplasty Versus Two Standard of Care Total Knee Arthroplasty Prostheses N/A
Completed NCT03660943 - A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain Phase 3
Recruiting NCT04531969 - Comparison of Outpatient and Inpatient Spa Therapy N/A
Completed NCT03643588 - The Comparison of HYAJOINT Plus and Hyalgan Hyaluronan Supplement for Knee Osteoarthritis Pain N/A
Not yet recruiting NCT04859764 - Effect of Reparel Knee Sleeve With Knee Injection N/A
Recruiting NCT04061733 - New Hydroxyethyl Cellulose Hydrogel for the Treatment of the Pain of Knee Arthrosis N/A
Recruiting NCT04051489 - A Novel Smartphone Application for "Smart" Knee Osteoarthritis Trials
Not yet recruiting NCT04381624 - Transcutaneous Vagal Stimulation in Knee Osteoarthritis (TRAVKO) N/A
Not yet recruiting NCT03225911 - Effect of a Lateral Wedge Insole and Simple Knee Sleeve in Individuals With Knee Osteoarthritis N/A
Recruiting NCT04120402 - Study to Evaluate the Efficacy and Safety of EP-104IAR in Patients With Osteoarthritis of the Knee Phase 2
Not yet recruiting NCT05026385 - The POMELO (Prevention Of MusclE Loss in Osteoarthritis) Trial N/A
Not yet recruiting NCT04875754 - A Study Evaluating the Safety, Tolerability, and Range of Biologically Active Doses of ICM-203 in Mild to Moderate Knee Osteoarthritis Phase 1/Phase 2
Not yet recruiting NCT04992624 - Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee Phase 2
Not yet recruiting NCT04885972 - Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis Phase 2
Not yet recruiting NCT04875052 - Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury N/A
Recruiting NCT02615522 - Prospective Post Market Clinical Follow-Up of the Primary Knee Endoprosthesis BPK-S Integration
Completed NCT03037489 - A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients Phase 2
Not yet recruiting NCT02826850 - Saphenous Nerve Radiofrequency for Knee Osteoarthritis Trial Phase 3
Completed NCT02944448 - A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee Phase 2
Completed NCT02901964 - Effect of Strengthening the Hip Abductor in Patients With Knee Osteoarthritis: Randomized Controlled Trial N/A