Osteoarthritis, Knee Clinical Trial
Official title:
Kliniske Smertetests Som prædiktorer for Effekten af GLA:D®-træningsforløb Hos Patienter Med Symptomgivende Slidgigt i knæene
Pain sensitization has been associated with pain severity in people with knee osteoarthritis
(KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients. In
addition, exercise-induced hypoalgesia (EIH), a measure of descending pain control, has
previously been found dysfunctional in a subgroup of people with painful KOA and has also
been utilized as a predictive factor for pain progression following total knee replacement.
Measures of pain sensitization have been used prognostic to identify responders to treatment
but EIH as a prognostic tool for Physiotherapy-guided Evidence-based Exercise Therapy (PEET)
has not been investigated. The primary aim of this explorative study is to investigate if EIH
assessed pre-PEET was associated with changes in pain, disability and PainDETECT (PDQ) score
post-PEET. The secondary aim is to investigate if PEET changes EIH and PDQ score in patients
with painful KOA.
Part 2:
Cross-sectional studies indicate, that daily level of activity influence the effectivity of
the EIH mechanims, while pain patients (e.g. KOA patients) can have normal of dysfunctional
EIH. It has not been investigated if EIH changes after prolonged exercise in healthy
subjects. The aim of this secord part of the study, is to investigate if EIH changes after
6-9 weeks of intensive military training in healthy subjects
n/a
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