Osteoarthritis, Knee Clinical Trial
Official title:
Association Between Preoperative Clinical Evaluation, Radiological Classifications and Histopathology in Patients With Knee Osteoarthritis Receiving a Prosthesis
Patients with osteoarthritis of the knee undergo visible joint changes in radiology and
Magnetic resonance imaging (MRI) tests, but also clinically and histologically. The area of
greatest change is at the subchondral/cartilage bone junction.
Investigators will determine the association between preoperative clinical evaluation (IKDC
and Womac scores), radiological classifications and histopathology.
In addition, the role of inflammation in the pathogenesis of osteoarthritis is being given
major interest, and inflammation is closely linked with vascularization. It was recently
demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could
identify the subchondral bone marrow vascularization changes occurring in osteoarthritis in
animals.
These changes appeared before cartilage lesions were visible and were correlated with
osteoarthritis severity. Thus the opportunity to obtain an objective assessment of bone
vascularization in non-invasive conditions in humans might help better understanding
osteoarthritis pathophysiology and finding new biomarkers. Investigators hypothesized that,
as in animals, DCE-MRI has the ability to identify subchondral bone marrow vascularization
changes in human osteoarthritis.
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