Osteoarthritis, Knee Clinical Trial
Official title:
Randomized, Placebo-controlled, Double-blind Trial to Evaluate the Efficacy and Safety of Topical Application of Tranexamic Acid for Saving Blood Losses in Patients Subjected to Prosthetic Knee Surgery
To compare the efficacy and safety of topical tranexamic acid versus placebo in patients diagnosed with severe knee osteoarthritis who will undergo prosthetic knee surgery in terms of saving blood loss (estimated blood loss, decreased hemoglobin and Decrease in hematocrit).
Tranexamic acid (Amchafibrin) exerts an antihemorrhagic activity by inhibiting the
fibrinolytic properties of plasmin. Tranexamic acid binds to plasminogen when it is
transformed into plasmin. The activity of the tranexamic acid-plasmin complex on fibrin
activity is less than the activity of free plasmin alone.
There are two methods of presentation: one, as an injectable solution; Two as a clear,
colorless aqueous solution.
Tranexamic acid in Spain is approved for use in the prevention and treatment of bleeding due
to general fibrinolysis. As for its specific indications the investigators find that it is
used for the treatment of metrorrhagia, menorrhagia, gastrointestinal hemorrhage, urinary
hemorrhagic disorders after prostate surgery, surgery of ears, nose, throat, gynecological,
thoracic, abdominal or cardiovascular or to counter associated hemorrhages To the
administration of a fibrinolytic drug.
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