Osteoarthritis, Knee Clinical Trial
Official title:
Does Synovitis Affect Treatment Efficacy in Intra-articular Injection Therapy to Osteoarthritis
To determine whether platelet-rich-plasma (PRP) or HA (hyaluronic acid)injection into synovitis in osteoarthritis(OA) knee can achieve improvement in knee function and reduce synovitis.
Methods:
sixty patients with OA knee having unilateral or bilateral synovitis validated by ultrasound
(N=40) were studied. All the patients were randomized to receive PRP (N=40) or Hyaluronic
acid(HA)(N=40) injection twice at 2-week intervals; Clinical assessments were performed using
a visual analog scale(VAS) and The Western Ontario and McMaster Universities Osteoarthritis
Index (WOMAC index) before injection at baseline, 4 weeks(first evaluation) and 12
weeks(secondary evaluation). Imaging evaluation based on color Doppler ultrasound(CDUS) and
the depth of synovial fluid accumulation ,and the width of synovial hypertrophy was performed
simultaneously.
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