Osteoarthritis, Knee Clinical Trial
Official title:
Which Factors Are the Strongest Predictors of a Positive Outcome After Physiotherapy for Patients With Knee Osteoarthritis?
Individuals with painful knee osteoarthritis (OA) experience restricted physical function.
Few previous studies have investigated comprehensive sets of constructs and tests to
investigate physical function in these patients. Most single studies of knee OA patients show
limited scope for explaining physical function in the perspective of WHO's International
Classification of Functioning, Disability and Health (ICF) 3 levels: Body functions (the
bodily level), Activities (individual level), and Participation (societal level). On the
bodily level there is limited case-control knowledge on muscle strength beyond the knee and
endurance-strength in general. On the activity level, there is similar limitation of
biomechanical bodily features in stair climbing. On the participation level the situation is
similar for objective performance. Measures are needed that inter-relate all three levels of
ICF. These should also include well discriminating tests e.g. knee strength, walking, and
activities of daily life (ADL), as well as both objective and subjective measures.
The purpose of this study is to explore mechanisms that can explain physical function in
patients with knee OA in primary care. The study's main and primary goal is to quantify which
baseline factors and change scores are the strongest predictors of a positive treatment
outcome in terms of patients' global perceived change after physiotherapy. Secondary research
question is: which factors are the strongest predictors of a positive outcome of
physiotherapy in knee OA, in terms of pain intensity, patient specific functional scale, and
function in daily living?
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