Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis

Status Active, not recruiting

Clinical Trial Summary

251 consecutive patients with knee arthrosis were randomized to one of three interventions: Four weekly injections of 2 ml isotonic saline (placebo), 2 ml sodium hyaluronate (hyaluronan) or 20 ml isotonic saline (excessive saline).

They all suffered from clinically and radiologically verified arthrosis of the knee with daily pain that did not respond to treatment with analgetics.

Results were evaluated at weeks 1,2,3,4,8,12,16 and 26. Biochemical markers for bone and cartilage degradation were measured in urine/blood.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00144820
Study type	Interventional
Source	Glostrup University Hospital, Copenhagen
Contact
Status	Active, not recruiting
Phase	Phase 4
Start date	May 1999
Completion date	November 2001

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